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Titolo:
LIPID-COMPOSITION OF NEURONAL CELL-BODIES AND NEURITES FROM CULTURED DORSAL-ROOT GANGLIA
Autore:
CALDERON RO; ATTEMA B; DEVRIES GH;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT BIOCHEM & MOLEC BIOPHYS,BOX 614,MCV STN RICHMOND VA 23298
Titolo Testata:
Journal of neurochemistry
fascicolo: 1, volume: 64, anno: 1995,
pagine: 424 - 429
SICI:
0022-3042(1995)64:1<424:LONCAN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; SCHWANN-CELLS; PLASMA-MEMBRANE; PHOSPHOLIPID ASYMMETRY; CHOLESTEROL; GANGLIOSIDES; LOCALIZATION; BIOSYNTHESIS; SPHINGOMYELIN; METABOLISM;
Keywords:
LIPID COMPOSITION; NEURONAL SOMA; NEURITIC PROCESSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.O. Calderon et al., "LIPID-COMPOSITION OF NEURONAL CELL-BODIES AND NEURITES FROM CULTURED DORSAL-ROOT GANGLIA", Journal of neurochemistry, 64(1), 1995, pp. 424-429

Abstract

The lipid composition of neuronal somata and neuritic processes of cultured root ganglia has been determined. Neuronal soma contained 37% of dry weight as lipid(15.4% cholesterol, 4.8% galactolipid, and 57.1% phospholipid). The major phospholipids were phosphatidylcholine and phosphatidyl ethanolamine. Galactolipids consisted of cerebroside and sulfatide in molar ratio 2:1. The neuronal soma contained tetrasialo-, disialo-, and monosialoganglioside. In contrast, neurites contained 15%of the dry weight as lipid (22.1% cholesterol, 7.7% galactolipid withcerebroside and sulfatide in molar ratio 2:1, and 56.4% total phospholipid). The neuritic galactolipid content was higher, as was the percentage of sphingomyelin, and phosphatidyl serine. The higher cholesterol content in neuritic lipid reflected the higher percentage of plasma membrane in this compartment. The ganglioside pattern of neurites was distinct from that of the neuronal soma and consisted entirely of gangliosides GQ1b, GT1b, GD1b, GD1a, and GD3, with no monosialogangliosides. The results indicate a preferential phospholipid and glycolipid sorting to the neuritic plasma membrane that may be related to the distinctive functions of this neuronal compartment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 02:12:45