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Titolo:
MIDAZOLAM DOES NOT ANTAGONIZE FENTANYL-MEDIATED ANALGESIA IN SURGICALPATIENTS
Autore:
BEHNE M; LISCHKE V; ASSKALI F; PROBST S; HERMANN R; VETTERMANN J;
Indirizzi:
UNIV FRANKFURT KLINIKUM,DEPT ANESTHESIOL & RESUSCITAT,THEODOR STERN KAI 7 D-60596 FRANKFURT GERMANY
Titolo Testata:
Journal of clinical anesthesia
fascicolo: 6, volume: 6, anno: 1994,
pagine: 481 - 486
SICI:
0952-8180(1994)6:6<481:MDNAFA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Keywords:
ANESTHESIA, INTRAVENOUS; DROPERIDOL, MIDAZOLAM; ANALGESIA, FENTANYL; SURGERY, BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
M. Behne et al., "MIDAZOLAM DOES NOT ANTAGONIZE FENTANYL-MEDIATED ANALGESIA IN SURGICALPATIENTS", Journal of clinical anesthesia, 6(6), 1994, pp. 481-486

Abstract

Study Objective: To determine whether midazolam possesses a clinically significant antianalgesic action in surgical patients. Design: Randomized, controlled study. Setting: Inpatient anesthesia at a universitydepartment of neurosurgery. Patients: 2 groups of to patients each who were scheduled for supratentorial brain surgery, did not have elevated intracranial pressure, and were free from systemic disease. Interventions: Patients underwent anesthesia induction With hexobarbital, succinylcholine and pancuronium; anesthesia was maintained with injections of droperidol-fentanyl (Group 1) or with midazolam-fentanyl (Group 2) following a predetermined repetitive dosing schedule, such that fentanyl 0.1 mg was injected upon predominant increases in heart rate, whereas droperidol 2.5 mg or midazolam 2.5 mg was injected upon increasesin blood pressure. Measurements and Main Results: Duration of anesthesia and invasiveness of surgery were similar in both groups. The amount of fentanyl required was 0.55 +/- 0.18 mg/hr (mean +/- SD) in Group 1 and 0.53 +/- 0.17 mg/hr in Group 2. Injections of droperidol 7.5 +/-3.4 mg/hr (Group 1) and midazolam 5.9 +/- 2.3 mg/hr (Group 2) were administered intraoperatively. This redosing regimen was associated withuninterrupted hemodynamic stability, indicating comparable and adequate anesthetic depth, Plasma concentrations of metabolites and hormonesindicative of humoral stress activation did not differ between groups. Conclusion: Under these clinical conditions, the administration of midazolam, when compared with droperidol, was not associated with signsof any antagonistic or antianalgesic action toward fentanyl-mediated analgesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:50:07