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Titolo:
PRETREATMENT WITH SEDATIVE-HYPNOTICS, BUT NOT WITH NONDEPOLARIZING MUSCLE-RELAXANTS, ATTENUATES ALFENTANIL-INDUCED MUSCLE RIGIDITY
Autore:
SANFORD TJ; WEINGER MB; SMITH NT; BENTHUYSEN JL; HEAD N; SILVER H; BLASCO TA;
Indirizzi:
VET AFFAIRS MED CTR,DEPT ANESTHESIOL,3350 LA JOLLA VILLAGE DR SAN DIEGO CA 92161 VET AFFAIRS MED CTR,DEPT ANESTHESIOL SAN DIEGO CA 92161
Titolo Testata:
Journal of clinical anesthesia
fascicolo: 6, volume: 6, anno: 1994,
pagine: 473 - 480
SICI:
0952-8180(1994)6:6<473:PWSBNW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Keywords:
ALFENTANIL; ELECTROMYOGRAPHY; MUSCLE RIGIDITY, OPIOID-INDUCED; PREMEDICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Sanford et al., "PRETREATMENT WITH SEDATIVE-HYPNOTICS, BUT NOT WITH NONDEPOLARIZING MUSCLE-RELAXANTS, ATTENUATES ALFENTANIL-INDUCED MUSCLE RIGIDITY", Journal of clinical anesthesia, 6(6), 1994, pp. 473-480

Abstract

Study Objective: To evaluate and compare the efficacy of various pretreatment agents to attenuate or prevent opioid-induced muscle rigidityusing a well-established, previously described clinical protocol. Design: Prospective, controlled, single-blind, partially randomized study. Setting: Large medical center. Patients: ASA physical status I-III patients undergoing elective surgical procedures of at least 3 hours' duration. Interventions: The effect of pretreatment with nondepolarizing muscle relaxants (atracirium 40 mu g/kg or metocurine 50 mu g/kg), benzodiazepine agonists (diazepam 5 mg or midazolam 2.5 mg), or thiopental sodium I mg/kg on the increased muscle tone produced by alfentanil175 mu g/kg was compared with a control group (given no pretreatment). Measurements and Main Results: Rigidity was assessed quantitatively by measuring the electromyographic activity of five muscle groups (biceps, intercostals, abdominals, quadriceps, and gastrocnemius). Rigidity also was rated qualitatively by attempts to initiate and maintain mash ventilation, attempts to flex an extremity, and the occurrence of myoclonic movements. Pretreatment with the two nondepolarizing muscle relaxants had no effect on the severe muscle rigidity produced by high-dose alfentanil. Whereas thiopental was only mildly effective, the benzodiazepines midazolam and diazepam significantly attenuated alfentanil rigidity (p < 0.05). Conclusion: This study suggests that benzodiazepine pretreatment is frequently, but not always, effective in preventing opioid-induced muscle rigidity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 08:07:18