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Titolo:
EFFECTS OF ALPRAZOLAM ON INCREASES IN HORMONAL AND ANXIETY LEVELS INDUCED BY META-CHLOROPHENYLPIPERAZINE
Autore:
SEVY S; BROWN SL; WETZLER S; KOTLER M; MOLCHO A; PLUTCHIK R; VANPRAAG HM;
Indirizzi:
BRONX MUNICIPAL HOSP CTR,DIV OUTPATIENT,NR 4S13,PELHAM PKWY S & EASTCHESTER RD BRONX NY 10461 MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DEPT PSYCHIAT BRONX NY 00000
Titolo Testata:
Psychiatry research
fascicolo: 3, volume: 53, anno: 1994,
pagine: 219 - 229
SICI:
0165-1781(1994)53:3<219:EOAOII>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; PANIC DISORDER; SEROTONIN AGONIST; NEURO-ENDOCRINE; CORTISOL SECRETION; HEALTHY-SUBJECTS; GROWTH-HORMONE; DOSE-RESPONSE; RAPHE NUCLEI; HUMANS;
Keywords:
SEROTONIN; CORTISOL; GROWTH HORMONE; PROLACTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
S. Sevy et al., "EFFECTS OF ALPRAZOLAM ON INCREASES IN HORMONAL AND ANXIETY LEVELS INDUCED BY META-CHLOROPHENYLPIPERAZINE", Psychiatry research, 53(3), 1994, pp. 219-229

Abstract

The effects of alprazolam, a triazolobenzodiazepine, on hormonal and behavioral responses induced by meta-chlorophenylpiperazine (MCPP), a serotonin receptor agonist, were investigated in 10 healthy men. Alprazolam (0.5 mg) or placebo was given 1 hour before MCPP (0.5 mg/kg) or placebo. Cortisol, prolactin, and growth hormone (GH) release, MCPP and alprazolam plasma levels, anxiety level, and panic symptoms were measured over 210 minutes. MCPP was found to increase cortisol, prolactin, GH, and anxiety levels. Alprazolam decreased cortisol and GH levels but had no effect on prolactin. When used in combination with MCPP, alprazolam blunted MCPP-induced cortisol and GH release, and it blocked the anxiogenic effects of MCPP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:25:13