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Titolo:
INDETERMINATE FINE-NEEDLE ASPIRATION BIOPSY OF THE THYROID - IDENTIFICATION OF SUBGROUPS AT HIGH-RISK FOR INVASIVE-CARCINOMA
Autore:
TYLER DS; WINCHESTER DJ; CARAWAY NP; HICKEY RC; EVANS DB;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT SURG ONCOL HOUSTON TX 00000 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT SURG ONCOL HOUSTON TX 00000 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT PATHOL HOUSTON TX 77030
Titolo Testata:
Surgery
fascicolo: 6, volume: 116, anno: 1994,
pagine: 1054 - 1060
SICI:
0039-6060(1994)116:6<1054:IFABOT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC SCORING SYSTEM; FROZEN-SECTION; FOLLOW-UP; MANAGEMENT; NODULES; SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Tyler et al., "INDETERMINATE FINE-NEEDLE ASPIRATION BIOPSY OF THE THYROID - IDENTIFICATION OF SUBGROUPS AT HIGH-RISK FOR INVASIVE-CARCINOMA", Surgery, 116(6), 1994, pp. 1054-1060

Abstract

Background. We examined the various cytologic features of indeterminate thyroid fine-needle aspirates along with known clinical and radiologic risk factors to determine whether any parameters were predictive of malignancy. Methods. Indeterminate fine-needle aspirates were prospectively categorized into four subgroups; (1) suspicious for papillary carcinoma, (2) follicular neoplasm, (3) Hurthle cell neoplasm, and (4)hypercellular follicular aspirates with colloid. Several clinical risk factors were examined, and subgroup comparisons were performed with Fisher's exact test. Results. Of 571 fine-needle aspirate cytologic findings 104 were interpreted as indeterminate for malignancy, and 81 patients underwent thyroidectomy. Invasive cancer was diagnosed in 9 to 10 lesions cytologically suspicious for papillary carcinoma, 8 of 43 follicular neoplasms, 5 of 18 Hurthle cell neoplasms, and 0 of 10 hypercellular aspirates. Cytologic subgroup (p < 0.0001) and age of 50 years or older (p = 0.008) were the only significant predictors of malignancy. When used together, age of so years or older and a cytologic diagnosis of follicular or Hurthle cell neoplasm also identified a subgroup of patients at high risk (9 of 20) of invasive malignancy. Conclusions. The majority of invasive cancers (18 of 22, 82%) were found in patients whose lesions were suspicious for papillary carcinoma or in patients 50 years or older with follicular or Hurthle cell neoplasms. The risk of carcinoma in these combined subgroups (18 of 30, 60%) warrantsearly surgical intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:31:00