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Titolo:
THE TRIS FORMULATION OF FLUOROURACIL IS MORE CARDIOTOXIC THAN THE SODIUM-SALT FORMULATIONS
Autore:
LEMAIRE L; MALETMARTINO MC; MARTINO R; DEFORNI M; LASSERRE B;
Indirizzi:
UNIV TOULOUSE 3,IMRCP LAB,RMN BIOMED GRP,118 ROUTE NARBONNE F-31062 TOULOUSE FRANCE UNIV TOULOUSE 3,IMRCP LAB,RMN BIOMED GRP F-31062 TOULOUSE FRANCE INST GUSTAVE ROUSSY F-77176 SAVIGNY FRANCE INST PHYSIOL,EQUIPE PHARMACOL REGULAT F-31400 TOULOUSE FRANCE
Titolo Testata:
Oncology Reports
fascicolo: 1, volume: 1, anno: 1994,
pagine: 173 - 174
SICI:
1021-335X(1994)1:1<173:TTFOFI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-FLUOROURACIL;
Keywords:
FLUOROURACIL; CARDIOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
L. Lemaire et al., "THE TRIS FORMULATION OF FLUOROURACIL IS MORE CARDIOTOXIC THAN THE SODIUM-SALT FORMULATIONS", Oncology Reports, 1(1), 1994, pp. 173-174

Abstract

The cardiotoxicity of 5-fluorouracil (FU) was attributed to degradation compounds present in the injected vials, fluoroacetaldehyde (Facet)and fluoromalonaldehydic acid (FMald). FU-NaOH vials were much less cardiotoxic than FU-Tris vials on the isolated perfused rabbit heart model since Facet and FMald are stored in stable depot forms in FU-Tris vials whereas, in FU-NaOH vials, they are extensively transformed. Cardiotoxic fluoroacetate (FAG), coming from Facet metabolization, was found in urine of patients, with a ratio FAC /FU catabolites 10-30 fold lower in patients treated with FU-NaOH than in those treated with FU-Tris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:28:42