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Titolo:
CONTROL OF TYPE-D GABAERGIC NEURON DIFFERENTIATION BY C-ELEGANS UNC-30 HOMEODOMAIN PROTEIN
Autore:
JIN YS; HOSKINS R; HORVITZ HR;
Indirizzi:
MIT,HOWARD HUGHES MED INST,DEPT BIOL,68-425,77 MASSACHUSETTS AVE CAMBRIDGE MA 02139 MIT,HOWARD HUGHES MED INST,DEPT BIOL CAMBRIDGE MA 02139 MRC,MOLEC BIOL LAB CAMBRIDGE CB2 2QH ENGLAND
Titolo Testata:
Nature
fascicolo: 6508, volume: 372, anno: 1994,
pagine: 780 - 783
SICI:
0028-0836(1994)372:6508<780:COTGND>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAENORHABDITIS-ELEGANS; NERVOUS-SYSTEM; GENE ENCODES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
Y.S. Jin et al., "CONTROL OF TYPE-D GABAERGIC NEURON DIFFERENTIATION BY C-ELEGANS UNC-30 HOMEODOMAIN PROTEIN", Nature, 372(6508), 1994, pp. 780-783

Abstract

THE Caenorhabditis elegans gene unc-30 is required for the develop ment and functioning of the 19 inhibitory GABAergic (gamma-aminobutyric-acid-secreting) type D motor neurons, which control locomotion(1-4). In unc-30 mutants the D neurons lack GABA(2) and have defects in axonalpathfinding and synaptic connections (J. White, personal communication). We report here that unc-30 encodes a homeodomain protein that is present in the nuclei of the D neurons at high levels in young larvae, in which the motor circuitry is formed, and at low levels in older animals. The UNC-30 protein is also present in six non-GABAergic neurons and is absent from the seven non-D-type GABAergic neurons. Ectopic expression of unc-30 induced GABA expression in cells that are normally not GABAergic. We propose that unc-30 functions as a transcriptional regulator within the type D neurons to control their terminal differentiation and that unc-30 is sufficient in some but not all cell types to induce GABA expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:01:35