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Titolo:
IMPLANTATION OF ALLOGENIC EMBRYONAL CHOND ROCYTES IN A COLLAGEN-FIBRINOGEN MATRIS INTO MECHANICAL INDUCED FULL-THICKNESS DEFECTS OF CHICK ARTICULAR-CARTILAGE
Autore:
PERKA C; LINDENHAYN K; HEILMANN HH; SITTINGER M; MUSCHIK M;
Indirizzi:
HUMBOLDT UNIV BERLIN,ORTHOPAD KLIN & POLIKLIN,FAC MED CHARITE D-10098BERLIN GERMANY
Titolo Testata:
Zeitschrift fur Orthopadie und Ihre Grenzgebiete
fascicolo: 6, volume: 134, anno: 1996,
pagine: 562 - 572
SICI:
0044-3220(1996)134:6<562:IOAECR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
GER
Soggetto:
ISOLATED EPIPHYSEAL; JOINT SURFACES; GRAFTS; INVITRO; REPAIR; GROWTH; BONE; TRANSPLANTATION; RECONSTRUCTION; ANTIGENICITY;
Keywords:
CHONDROCYTE TRANSPLANTATION; EMBRYONAL CELL CULTURE; NUTRITION DEPENDING CELL DIFFERENTIATION; CARTILAGE DEFECT REPAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
C. Perka et al., "IMPLANTATION OF ALLOGENIC EMBRYONAL CHOND ROCYTES IN A COLLAGEN-FIBRINOGEN MATRIS INTO MECHANICAL INDUCED FULL-THICKNESS DEFECTS OF CHICK ARTICULAR-CARTILAGE", Zeitschrift fur Orthopadie und Ihre Grenzgebiete, 134(6), 1996, pp. 562-572

Abstract

Full thickness defects (diameter 1,7 mm, depth 2,5 mm) were created mechanically in articular cartilage and subchondral bone of the condyles of tibiotarsal joints of 9-month old chickens. This full-thickness defects were repaired with cultured allogenic embryonic chick epiphyseal chondrocytes from the tibiae and femura of 10-days-old chicken embryons. The cells were embedded in a collagen-fibrinogen-matrix. Controlswere similary operated, but received either no treatment or implant; the delivery substance only. Healing of the defects was observed macroscopically, histologically. histochemically and histomorphometrically after 3, 12 and 23 weeks, This graft was succesfully transplanted in mechanically induced defects in 80%. The resulting hyaline cartilage was structurally reorganized according to the host pattern and under theinfluence of environmental conditions. The articular zone preserved its cartilaginous phenotype. whereas the subchondral regions were transformed into bone. 12 weeks after the operation the defects in the experimental group were completely filled. In all instances in this group,there was an initial extreme increase of mitotic rate and cell number, After 24 weeks normal and subnormal values were founded. The defectsin the control groups healed with fibrocartilage. Our results showed,that only the defects in the experimental group were completly filledwith reparative hyaline cartilage tissue. In the present study the mixture of cultured allogenic embryonic chondrocytes and a collagen-fibrinogen-matrix was used succesfully as a transplant for repairing defects in articular cartilage of chickens. Thus allogenic transplantation of cultured embryonal chondrocytes appears to be one of the most promising methods for the restoration of articular cartilage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:42:56