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Titolo:
QUANTITATIVE COMPARISON OF SINGLE-ISOTOPE AND DUAL-ISOTOPE STRESS-REST SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHIC IMAGING FOR REVERSIBILITY OF DEFECTS
Autore:
SIEBELINK HMJ; NATALE D; SINUSAS AJ; WACKERS FJT;
Indirizzi:
YALE UNIV,SCH MED,CARDIOVASC NUCL IMAGING LABS,DEPT DIAGNOST RADIOL,333 CEDAR ST,TE-2 NEW HAVEN CT 06520 YALE UNIV,SCH MED,CARDIOVASC NUCL IMAGING LABS,DEPT DIAGNOST RADIOL NEW HAVEN CT 06520 YALE UNIV,SCH MED,CARDIOVASC NUCL IMAGING LABS,DEPT MED NEW HAVEN CT 06520
Titolo Testata:
Journal of nuclear cardiology
fascicolo: 6, volume: 3, anno: 1996,
parte:, 1
pagine: 483 - 493
SICI:
1071-3581(1996)3:6<483:QCOSAD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY-DISEASE; HEXAKIS 2-METHOXYISOBUTYL ISONITRILE; METHOXY ISOBUTYL ISONITRILE; MYOCARDIAL PERFUSION; VIABLE MYOCARDIUM; TC-99M SESTAMIBI; TECHNETIUM-99M-METHOXYISOBUTYL ISONITRILE; VENTRICULAR DYSFUNCTION; CARDIAC PHANTOM; INFARCT SIZE;
Keywords:
MYOCARDIAL PERFUSION IMAGING; SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY; DUAL ISOTOPE; SESTAMIBI; THALLIUM 201; QUANTIFICATION; STRESS; REST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
H.M.J. Siebelink et al., "QUANTITATIVE COMPARISON OF SINGLE-ISOTOPE AND DUAL-ISOTOPE STRESS-REST SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHIC IMAGING FOR REVERSIBILITY OF DEFECTS", Journal of nuclear cardiology, 3(6), 1996, pp. 483-493

Abstract

Background Dual-isotope rest/stress single-photon emission computed tomographic (SPECT) imaging is a time-saving imaging protocol, However,the stress radiotracer, technetium 99m-labeled sestamibi, and the rest radiotracer, thallium 201, have different physical properties and myocardial kinetics, In patients with abnormal resting myocardial perfusion, these differences may affect quantification of rest defect size and defect reversibility, The purpose of the study was to compare myocardial perfusion defect reversibility quantitatively by single-isotope (rest/stress sestamibi) and dual-isotope (rest thallium/stress sestamibi) SPECT. Methods and Results. Thirty patients with prior myocardial infarction underwent rest/stress sestamibi SPECT imaging and rest thallium SPECT imaging, Defects were quantified according to circumferential count profiles with a normal sestamibi database, The images of a subgroup of 21 patients were processed with radiotracer-specific normal databases, Defect size and defect reversibility were compared quantitatively for single-isotope and dual-isotope SPECT, Rest sestamibi defect size was significantly larger than rest thallium defect size (19 +/-15 vs 14 +/- 16; p = 0.007), Defect reversibility was larger with thallium than with sestamibi (10 +/- 9 vs 6 +/- 6; p = 0.002), With radiotracer-specific normal databases, mean rest sestamibi and thallium defect sizes in 21 patients were not different (23 +/- 19 vs 21 +/- 17; difference not significant), With radiotracer-specific normal databases, mean defect reversibility was not different with either sestamibi orthallium (6 +/- 6 vs 8 +/- 9; difference not significant), although correlation among individual patients was only fair (r(2) = 0.48). Conclusion: In patients with prior myocardial infarction, stress-induced defect reversibility is quantitatively larger with dual-isotope imagingthan with single-isotope imaging, Quantitative processing of dual-isotope images requires radiotracer-specific normal databases, Because ofdifferent characteristics of sestamibi and thallium, assessment of defect reversibility on dual-isotope images should be made with caution,Only relatively large defect reversibility can be assumed to represent true stress-induced myocardial ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:59:31