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Titolo:
SEDATION WITH MEPERIDINE AND MIDAZOLAM IN PEDIATRIC-PATIENTS UNDERGOING ENDOSCOPY
Autore:
BAHALOMARA N; NAHATA MC; MURRAY RD; LINSCHEID TR; FISHBEIN M; HEITLINGER LA; LI BUK; MCCLUNG HJ; POTTER C; LININGER B;
Indirizzi:
OHIO STATE UNIV,COLL PHARM,500 W 12TH AVE COLUMBUS OH 43210 OHIO STATE UNIV,COLL MED COLUMBUS OH 43210 CHILDRENS HOSP,WEXNER INST PEDIAT RES COLUMBUS OH 43205
Titolo Testata:
European Journal of Clinical Pharmacology
fascicolo: 4, volume: 47, anno: 1994,
pagine: 319 - 323
SICI:
0031-6970(1994)47:4<319:SWMAMI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER GASTROINTESTINAL ENDOSCOPY; PREMEDICATION; DIAZEPAM; CHILDREN; AGE;
Keywords:
MEPERIDINE; MIDAZOLAM; SEDATION, ENDOSCOPY, CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
N. Bahalomara et al., "SEDATION WITH MEPERIDINE AND MIDAZOLAM IN PEDIATRIC-PATIENTS UNDERGOING ENDOSCOPY", European Journal of Clinical Pharmacology, 47(4), 1994, pp. 319-323

Abstract

We conducted a randomized, double-blind trial evaluating the efficacyand safety of meperidine 2 mg.kg(-1) (M) and meperidine 2 mg.kg(-1) plus midazolam 0.05 mg.kg(-1) (M + M) in 40 pediatric outpatients (age 1 to 17 years) undergoing upper endoscopy procedures. The physician and nurse performing the procedure were asked to rate cooperation, emotional status, drowsiness, and overall efficacy. A blinded observer recorded the frequency of negative behaviors indicating distress, vital signs, and oxygen saturation before, during, and after the procedure. Nosignificant differences were noted in the overall efficacy of the regimens. Good or excellent efficacy was noted in 15 of 21 children (71 %) in the M group and 15 of 19 children (79 %) in the M + M group by physicians; nurses assigned a good or excellent rating for 14 of 21 (67 %) and 13 of 19 (68 %) in the M and M + M groups, respectively. Immediately following the procedure, amnesia was noted in 4 of 17 (23 %) patients who received M versus 14 of 18 (78 %) patients who received M + M (P = 0.002). Of the children who received M + M, the amnesia tended to occur more frequently in older children (> 11 years, 8 children, rate of amnesia 100 %) than in younger children (less than or equal to 11 years, 6 of 10 evaluable children, rate of amnesia 60 %). There was no significant difference between the frequency of negative behaviors,rate of adverse effects, or changes in vital signs or oxygen saturation noted with the two drug regimens. We conclude that although the twosedation regimens produced similar efficacy, the combination of M + Mmay be preferred over M alone to enhance amnesia. Additional trials of M + M for sedation prior to other procedures are needed.

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Documento generato il 16/07/20 alle ore 06:38:58