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Titolo:
IMMUNOHISTOCHEMICAL STUDY OF NEUTROPHIL-TYPE AND FIBROBLAST-TYPE COLLAGENASES AND STROMELYSIN-1 IN ADULT PERIODONTITIS
Autore:
INGMAN T; SORSA T; MICHAELIS J; KONTTINEN YT;
Indirizzi:
UNIV HELSINKI,DEPT ANAT,POB 9 SF-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT MED CHEM HELSINKI FINLAND UNIV HELSINKI,DEPT PERIODONTOL SF-00300 HELSINKI FINLAND CHRISTCHURCH HOSP,SCH MED,DEPT PATHOL CHRISTCHURCH NEW ZEALAND
Titolo Testata:
Scandinavian Journal of Dental Research
fascicolo: 6, volume: 102, anno: 1994,
pagine: 342 - 349
SICI:
0029-845X(1994)102:6<342:ISONAF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GINGIVAL CREVICULAR FLUID; POLYMORPHONUCLEAR LEUKOCYTE COLLAGENASE; MATRIX METALLOPROTEINASE-3 STROMELYSIN; INTERSTITIAL COLLAGENASES; JUVENILE PERIODONTITIS; SALIVARY COLLAGENASE; PROCOLLAGENASE; IDENTIFICATION; GELATINASE; PROTEASES;
Keywords:
COLLAGENASES; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASES; PERIODONTITIS; STROMELYSIN-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T. Ingman et al., "IMMUNOHISTOCHEMICAL STUDY OF NEUTROPHIL-TYPE AND FIBROBLAST-TYPE COLLAGENASES AND STROMELYSIN-1 IN ADULT PERIODONTITIS", Scandinavian Journal of Dental Research, 102(6), 1994, pp. 342-349

Abstract

Eight adult periodontitis (AP) patients were studied immunohistochemically to determine the presence of matrix metalloproteinases (MMPs) MMP-1, MMP-3, and MMP-8 in the marginal gingival and gingival granulation tissue specimens obtained from periodontal flap surgery after scaling and root planing. Clinically healthy gingival tissue specimens obtained from impacted third-molar extraction operations served as controls. MMP-type-specific antisera were applied by the avidin-biotin-peroxidase complex staining method. Moderate immunoreactivity for neutrophil collagenase (MMP-8) was found both in the AP patients' marginal gingival connective tissue and in gingival granulation tissue specimens. Immunoreactivity for fibroblast-type collagenase (MMP-1) and stromelysin-1 (MMP-3) was detected only in the AP patients' gingival granulation tissue specimens. In the control specimens, no immunoreactivity for theMMPs could be detected. For the first time, this finding demonstratesimmunohistochemically the presence of MMP-8 in human inflamed gingivain situ, and further highlights the importance of MMP-8 in periodontal tissue destruction, evidently during the acute phase(s) of the disease. However, our results confirm and extend previous studies indicating that other types of MMPs from resident gingival cell sources also seem to participate in the chronic and destructive course of periodontalinflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:51:10