Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CLOZAPINE-INDUCED TRANSIENT WHITE BLOOD-COUNT DISORDERS
Autore:
HUMMER M; KURZ M; BARNAS C; SARIA A; FLEISCHHACKER WW;
Indirizzi:
INNSBRUCK UNIV CLIN,DEPT PSYCHIAT,BIOL PSYCHIAT RES UNIT,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV CLIN,DEPT PSYCHIAT,BIOL PSYCHIAT RES UNIT,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
The Journal of clinical psychiatry
fascicolo: 10, volume: 55, anno: 1994,
pagine: 429 - 432
SICI:
0160-6689(1994)55:10<429:CTWBD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AGRANULOCYTOSIS; UNITED-STATES; SCHIZOPHRENIA; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M. Hummer et al., "CLOZAPINE-INDUCED TRANSIENT WHITE BLOOD-COUNT DISORDERS", The Journal of clinical psychiatry, 55(10), 1994, pp. 429-432

Abstract

Background: The aim of the study was to shed more light on the incidence and course of clozapine-induced transient white blood count (WBC) disorders. Method: In an analysis of our clozapine drug monitoring program, we evaluated the data of 68 patients receiving clozapine for thefirst time. Incidence rates were calculated by actuarial life table analysis. The potential influence of sex, age, dose, and plasma level was evaluated using discriminant analysis. Results: Two patients developed progressive neutropenia, leading to agranulocytosis in one case. We also found the following transient hematologic dysfunctions: neutropenia (22.0%), eosinophilia (61.7%), and leukocytosis (40.9%). One patient showed chronic leukocytosis. Additionally, minor changes in the number of lymphocytes, monocytes, and basophilic granulocytes were detected in the study population. Conclusion: Hematologic side effects are frequently induced by the atypical antipsychotic clozapine. Next to agranulocytosis, a progressive and potentially lethal hematologic adverse effect, most of the WBC disorders are transient and appear to be harmless.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:04:18