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Titolo:
CHILDHOOD-ONSET SCHIZOPHRENIA - AN NIMH STUDY IN PROGRESS
Autore:
GORDON CT; FRAZIER JA; MCKENNA K; GIEDD J; ZAMETKIN A; ZAHN T; HOMMER D; HONG W; KAYSEN D; ALBUS KE; RAPOPORT JL;
Indirizzi:
NIMH,CHILD PSYCHIAT BRANCH,BLDG 10,RM 6N240,9000 ROCKVILLE PIKE BETHESDA MD 20892 NIMH,CHILD PSYCHIAT BRANCH BETHESDA MD 20892 NIMH,PSYCHOL & PSYCHOPATHOL LAB BETHESDA MD 20892 NIA,NEUROSCI LAB BETHESDA MD 20892 NIAAA,CLIN STUDIES LAB BETHESDA MD 20892
Titolo Testata:
Schizophrenia bulletin
fascicolo: 4, volume: 20, anno: 1994,
pagine: 697 - 712
SICI:
0586-7614(1994)20:4<697:CS-ANS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM ACTIVITY; POSITRON EMISSION TOMOGRAPHY; MONOZYGOTIC TWINS DISCORDANT; MAJOR DEPRESSIVE DISORDER; WHOLE-BLOOD SEROTONIN; PURSUIT EYE-MOVEMENTS; AUTISTIC-CHILDREN; SMOOTH-PURSUIT; CORPUS-CALLOSUM; GLUCOSE-UTILIZATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
111
Recensione:
Indirizzi per estratti:
Citazione:
C.T. Gordon et al., "CHILDHOOD-ONSET SCHIZOPHRENIA - AN NIMH STUDY IN PROGRESS", Schizophrenia bulletin, 20(4), 1994, pp. 697-712

Abstract

An ongoing study of the phenomenology, genetics, neuropsychology, physiology (eye tracking, autonomic responsivity), neuroimaging, biochemistry, and pharmacology of childhood-onset schizophrenia is described, and pilot data are presented for the first 22 subjects. Differentiation from autism ''spectrum'' disorders and other poorly defined, severe neurodevelopmental disorders is needed. Eye tracking and autonomic results are similar to patterns seen in later-onset schizophrenia and possibly more striking Magnetic resonance imaging showed larger left frontal ventricular horn area for the schizophrenia subjects, larger left caudate, and lack of normal caudate asymmetry. Fluorodeoxyglucose positron emission tomography during an auditory continuous performance task revealed decreased right parietal/ occipital glucose metabolic rate in the schizophrenia subjects, which may be secondary to poor attentional performance, and increased glucose metabolic rate in three left frontal regions, a left parietal region, and the right putamen. Clozapine has been effective and well tolerated in an open trial with 12 adolescents who responded poorly to typical neuroleptics; 16 subjects have been enrolled in a double-blind comparison of haloperidol and clozapine. Longitudinal study of this narrowly defined and possibly more homogeneous group of very early-onset schizophrenia subjects will be relevant to current neurodevelopmental theories addressing the role of puberty, progression of pathology, and continuity or discontinuity with later-onset schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:17:54