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Titolo:
GENOMIC ANALYSIS OF A NEW MAMMALIAN DISTAL-LESS GENE - DIX7
Autore:
NAKAMURA S; STOCK DW; WYDNER KL; BOLLEKENS JA; TAKESHITA K; NAGAI BM; CHIBA S; KITAMURA T; FREELAND TM; ZHAO ZY; MINOWADA J; LAWRENCE JB; WEISS KM; RUDDLE FH;
Indirizzi:
YALE UNIV,DEPT BIOL NEW HAVEN CT 06511 YALE UNIV,DEPT BIOL NEW HAVEN CT 06511 PENN STATE UNIV,DEPT ANTHROPOL UNIVERSITY PK PA 16802 UNIV MASSACHUSETTS,SCH MED,DEPT CELL BIOL WORCESTER MA 01655 MT SINAI HOSP,DIV MOL & DEV BIOL TORONTO ON M5G 1X5 CANADA NYU,MED CTR,DEPT MED NEW YORK NY 10016 STANFORD UNIV,SCH MED STANFORD CA 94305 UNIV TOKYO,FAC MED,DEPT MED 3 TOKYO 113 JAPAN DNAX RES INST MOL & CELLULAR BIOL INC PALO ALTO CA 94304 FUJISAKI CELL CTR,HAYASHIBARA BIOCHEM LABS OKAYAMA 702 JAPAN
Titolo Testata:
Genomics
fascicolo: 3, volume: 38, anno: 1996,
pagine: 314 - 324
SICI:
0888-7543(1996)38:3<314:GAOANM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMEOBOX GENE; LIMB DEVELOPMENT; DEVELOPING FOREBRAIN; CRANIOFACIAL DEVELOPMENT; RESTRICTED EXPRESSION; DROSOPHILA EMBRYO; MOUSE; CLONING; DNA; HOMEODOMAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
S. Nakamura et al., "GENOMIC ANALYSIS OF A NEW MAMMALIAN DISTAL-LESS GENE - DIX7", Genomics, 38(3), 1996, pp. 314-324

Abstract

We have cloned a new Dlx gene (Dlx7) from human and mouse that may represent the mammalian orthologue of the newt gene NvHBox-5. The homeodomains of these genes are highly similar to all other vertebrate Dlx genes, and regions of similarity also exist between mammalian Dlx7 and a subset of vertebrate Dlx genes downstream of the homeodomain. The sequence divergence between human and mouse Dlx7 in these regions is greater than that predicted from comparisons of other vertebrate Dlx genes, however, and there is little sequence similarity upstream of the homeodomain both between these two genes and with other Dlx genes. We present evidence for alternative splicing of mouse Dlx7 upstream of the homeodomain that may account for some of this divergence. We have mapped human DLX7 distal to the 5' end of the HOXB cluster at an estimateddistance of between 1 and 2 Mb by FISH. Both the human and the mouse Dlx7 are shown to be closely linked to Dlx3 in a convergently transcribed orientation. These mapping results support the possibility that vertebrate distal-less genes have been duplicated in concert with the Hox clusters. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:11:35