Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AN EVALUATION OF I-123 IODOAZOMYCINARABINOSIDE AS A MARKER OF LOCALIZED TISSUE HYPOXIA IN PATIENTS WITH DIABETES-MELLITUS
Autore:
ALARAFAJ A; RYAN EA; HUTCHISON K; MANNAN RH; MERCER J; WIEBE LI; MCEWAN AJB;
Indirizzi:
CROSS CANC INST,11560 UNIV AVE EDMONTON T6G 1Z2 AB CANADA CROSS CANC INST EDMONTON T6G 1Z2 AB CANADA UNIV ALBERTA HOSP EDMONTON T6G 2B7 AB CANADA UNIV ALBERTA EDMONTON AB CANADA
Titolo Testata:
European journal of nuclear medicine
fascicolo: 12, volume: 21, anno: 1994,
pagine: 1338 - 1342
SICI:
0340-6997(1994)21:12<1338:AEOIIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR HYPOXIA; ARABINOSIDE; PERFUSION; BINDING;
Keywords:
I-123 IODOAZOMYCINARABINOSIDE; HYPOXIA; DIABETES MELLITUS; PERIPHERAL VASCULAR DISEASE; RADIONUCLIDE IMAGING;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
A. Alarafaj et al., "AN EVALUATION OF I-123 IODOAZOMYCINARABINOSIDE AS A MARKER OF LOCALIZED TISSUE HYPOXIA IN PATIENTS WITH DIABETES-MELLITUS", European journal of nuclear medicine, 21(12), 1994, pp. 1338-1342

Abstract

Peripheral vascular disease is a serious and common complication in patients with diabetes mellitus (DM). Evaluation is, conventionally. bytranscutaneous oxygen tension measurements (TcpO(2)), although this technique has some limitations in the evaluation of tissue viability. We have evaluated a new, radiolabelled, in vivo marker of tissue hypoxia, iodoazomycinarabinoside (IAZA), by comparing TcpO(2) measurements with patterns of iodine-123 IAZA uptake in ten patients (19 lower limbs) with DM and peripheral vascular disease using conventional gamma camera imaging techniques. Normal uptake patterns were seen in limbs in which normal TcpO(2) measurements were obtained. Diffusely increased uptake of [123]IAZA was seen in limbs with reduced TcpO(2). Focally increased uptake was seen in ulcers or in areas of atrophic skin change. Asemiquantitative measure showed an inverse correlation between [123]IAZA and TcpO(2) values. These data suggest that tissue hypoxia can be imaged in this population of patients and that severity of disease canbe assessed. A longitudinal prospective trial is now being developed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:03:57