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Titolo:
SEDATION FOR UPPER GASTROINTESTINAL ENDOSCOPY - A COMPARISON OF ALFENTANIL-MIDAZOLAM AND MEPERIDINE-DIAZEPAM
Autore:
DONNELLY MB; SCOTT WAC; DALY DS;
Indirizzi:
MONTREAL GEN HOSP,DEPT ANAESTHESIA,1650 CEDAR AVE MONTREAL H3G 1A4 PQCANADA MONTREAL GEN HOSP,DEPT ANAESTHESIA MONTREAL H3G 1A4 PQ CANADA MONTREAL GEN HOSP,DEPT GASTROENTEROL MONTREAL H3G 1A4 PQ CANADA MCGILL UNIV MONTREAL H3G 1A4 PQ CANADA
Titolo Testata:
Canadian journal of anaesthesia
fascicolo: 12, volume: 41, anno: 1994,
pagine: 1161 - 1165
SICI:
0832-610X(1994)41:12<1161:SFUGE->2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-SATURATION; BENZODIAZEPINE SEDATION; RECOVERY; PREMEDICATION; GASTROSCOPY; PETHIDINE; REVERSAL;
Keywords:
ANESTHESIA, SEDATION; ANALGESICS, ALFENTANIL MEPERIDINE; HYPNOTICS, BENZODIAZEPINES, MIDAZOLAM, DIAZEPAM; SURGERY, ENDOSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Donnelly et al., "SEDATION FOR UPPER GASTROINTESTINAL ENDOSCOPY - A COMPARISON OF ALFENTANIL-MIDAZOLAM AND MEPERIDINE-DIAZEPAM", Canadian journal of anaesthesia, 41(12), 1994, pp. 1161-1165

Abstract

The authors studied the efficacy and cost of substituting sedation using midazolam and alfentanil for the existing regimen of diazepam and meperidine in patients requiring upper gastrointestinal endoscopy. Sixty consenting subjects were randomized to receive either meperidine 50mg with diazepam approximately 90 mu g.kg-1 (Group D) or alfentanil 250 mu g with midazolam approximately 50 mu g.kg(-1) (Group M). Endoscope insertion time, patient acceptance, apnoeic or desaturation episodes were noted by a physician observer. Pulse oximetry was used to monitor heart rate and oxygen saturation (SpO(2) during endoscopy. Subjectsperformed four-choice reaction time (4CRT) tests before, 30 and 60 min after endoscopy, and were assessed for nausea or dizziness and theirability to stand and walk. During endoscopy, insertion time was shorter 184 +/- 45 sec vs 122 +/- 83 sec, P < 0.03) and fewer aversive movements occurred (0.4 +/- 0.6 vs 1.7 +/- 2.4, P < 0.005) in Group M thanGroup D. No subject in either group suffered any apnoea or prolonged desaturation requiring supplemental oxygen Irrespective of treatment group, greater decreases in SpO(2) (6.1 +/- 3.4% vs 3.6 +/- 2.2%, P < 0.001) occurred in subjects >45 yr of age than in subjects less than orequal to 45 yr. During recovery 4CRT values at 30 min after endoscopywere longer (723 +/- 226 msec vs 594 +/- 139 msec, P < 0.005) in Group M than in Group D but not after 60 min. It was concluded that the small differences in endoscopy conditions and greater sedation during the first 30 min of recovery did not justify the additional cost of using midazolam and alfentanil.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:54:00