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Titolo:
ALU REPEATED DNAS ARE DIFFERENTIALLY METHYLATED IN PRIMATE GERM-CELLS
Autore:
RUBIN CM; VANDEVOORT CA; TEPLITZ RL; SCHMID CW;
Indirizzi:
UNIV CALIF DAVIS,MOLEC & CELL BIOL SECT DAVIS CA 95616 UNIV CALIF DAVIS,CALIF REG PRIMATE RES CTR DAVIS CA 95616 UNIV CALIF DAVIS,DEPT MED PATHOL DAVIS CA 95616 UNIV CALIF DAVIS,DEPT CHEM DAVIS CA 95616
Titolo Testata:
Nucleic acids research
fascicolo: 23, volume: 22, anno: 1994,
pagine: 5121 - 5127
SICI:
0305-1048(1994)22:23<5121:ARDADM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE EMBRYO; GENES; SEQUENCES; PATTERNS; CPG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Rubin et al., "ALU REPEATED DNAS ARE DIFFERENTIALLY METHYLATED IN PRIMATE GERM-CELLS", Nucleic acids research, 22(23), 1994, pp. 5121-5127

Abstract

A significant fraction of Alu repeats in human sperm DNA, previously found to be unmethylated, is nearly completely methylated in DNA from many somatic tissues. A similar fraction of unmethylated Alus is observed here in sperm DNA from rhesus monkey. However, Alus are almost completely methylated at the restriction sites tested in monkey follicular oocyte DNA. The Alu methylation patterns in mature male and female monkey germ cells are consistent with Alu methylation in human germ cell tumors. Alu sequences are hypomethylated in seminoma DNAs and more methylated in a human ovarian dysgerminoma. These results contrast withmethylation patterns reported for germ cell single-copy, CpG island, satellite, and L1 sequences. The function of Alu repeats is not known,but differential methylation of Alu repeats in the male and female germ lines suggests that they may serve as markers for genomic imprinting or in maintaining differences in male and female meiosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 18:11:22