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Titolo:
CYCLIC CMP FORMATION IN RAT CEREBELLAR SLICES IS STIMULATED BY ENDOTHELINS VIA NITRIC-OXIDE FORMATION AND BY SARAFOTOXINS VIA FORMATION OF CARBON-MONOXIDE
Autore:
SHRAGALEVINE Z; GALRON R; SOKOLOVSKY M;
Indirizzi:
TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,NEUROBIOCHEM LAB IL-69978 TEL AVIV ISRAEL TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,NEUROBIOCHEM LAB IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Biochemistry
fascicolo: 49, volume: 33, anno: 1994,
pagine: 14656 - 14659
SICI:
0006-2960(1994)33:49<14656:CCFIRC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUANYLATE-CYCLASE; RECEPTOR; RELAXATION; AORTA; HYDROLYSIS; ACTIVATION; SUBTYPE; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
Z. Shragalevine et al., "CYCLIC CMP FORMATION IN RAT CEREBELLAR SLICES IS STIMULATED BY ENDOTHELINS VIA NITRIC-OXIDE FORMATION AND BY SARAFOTOXINS VIA FORMATION OF CARBON-MONOXIDE", Biochemistry, 33(49), 1994, pp. 14656-14659

Abstract

Involvement of a cyclic GMP pathway in signal transduction stimulatedby endothelins (ETs) and sarafotoxins (SRTXs) was explored using rat cerebellar slices. These peptides activated the same receptor binding sites (ET-1 and SRTX-b at the picomolar sites; ET-3 and SRTX-c at the nanomolar sites) to produce cyclic GMP, but their signaling pathways differed. The endothelins (ET-1 and ET-3) were found to signal via nitric oxide formation and to involve pertussis toxin-sensitive G-protein(s), The SRTXs (b and c), while also stimulating cyclic GMP production,did so via a pathway which is not L-arginine-dependent, i.e., carbon monoxide formation, and did not involve pertussis-toxin-sensitive G-protein(s). This is the first demonstration that the signaling pathways of endothelins and sarafotoxins may differ, even though they share thesame binding sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:37:10