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Titolo:
PHASE-III EVALUATION OF 4 DOSES OF MEGESTROL-ACETATE AS THERAPY FOR PATIENTS WITH CANCER ANOREXIA AND OR CACHEXIA/
Autore:
LOPRINZI CL; BERNATH AM; SCHAID DJ; MALLIARD JA; ATHMANN LM; MICHALAK JC; TSCHETTER LK; HATFIELD AK; MORTON RF;
Indirizzi:
GEISINGER CLIN ONCOL PROGRAM DANVILLE PA 17822 GEISINGER CLIN ONCOL PROGRAM DANVILLE PA 17822 MAYO CLIN & MAYO FDN,DIV MED ONCOL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,CTR CANC,STAT UNIT ROCHESTER MN 55905 CREIGHTON UNIV,MED CTR,NEBRASKA ONCOL GRP OMAHA NE 00000 CCOP,DULUTH CLIN DULUTH MN 00000 SIOUXLAND HEMATOL ONCOL ASSOCIATES SIOUX CITY IA 00000 CCOP,SIOUX COMMUNITY CANC CONSORTIUM SIOUX FALLS SD 00000 CCOP,CARLE CANC CTR URBANA IL 00000 CCOP,IOWA ONCOL RES ASSOC DES MOINES IA 00000
Titolo Testata:
Oncology
, volume: 51, anno: 1994, supplemento:, 1
pagine: 2 - 7
SICI:
0030-2414(1994)51:<2:PEO4DO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED BREAST-CANCER; CONTROLLED TRIAL; STANDARD; APPETITE; WEIGHT; WOMEN;
Keywords:
CANCER; CHEMOTHERAPY; ANOREXIA; CACHEXIA; MEGESTROL ACETATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
C.L. Loprinzi et al., "PHASE-III EVALUATION OF 4 DOSES OF MEGESTROL-ACETATE AS THERAPY FOR PATIENTS WITH CANCER ANOREXIA AND OR CACHEXIA/", Oncology, 51, 1994, pp. 2-7

Abstract

Several randomized, placebo-controlled clinical trials have demonstrated that megestrol acetate therapy can result in appetite stimulation and nonfluid weight gain in patients with cancer anorexia/cachexia. The present trial was designed to compare megestrol acetate doses ranging from 160 to 1,280 mg/day. This trial randomly assigned 342 evaluablepatients with cancer anorexia/cachexia to receive oral megestrol acetate at doses of 160, 480, 800 and 1,280 mg/day. Patients were evaluated monthly by history, examination and patient-completed questionnaires, as well as by serum albumin levels. The data demonstrate a positive dose-response effect for megestrol acetate on appetite stimulation (p = 0.02). There was a trend for more nonfluid weight gain with higher drug doses. Megestrol acetate was well tolerated in this group of patients with advanced malignant disease. The positive dose-response effectobserved for megestrol acetate on appetite stimulation supports both the prestudy hypothesis and findings in the literature. The optimal dose in this study seemed to be 800 mg/day; no further benefit was derived from using the higher dose. Nonetheless, it may be reasonable to start with lower initial doses in routine clinical practice, taking intoaccount dosage form, availability and cost of therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:09:05