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Titolo:
EFFECT OF CURRENT MAGNITUDE AND DRUG CONCENTRATION ON IONTOPHORETIC DELIVERY OF OCTREOTIDE ACETATE (SANDOSTATIN(R)) IN THE RABBIT
Autore:
LAU DTW; SHARKEY JW; PETRYK L; MANCUSO FA; YU ZL; TSE FLS;
Indirizzi:
SANDOZ PHARMACEUT CORP,SANDOZ RES INST,TECH RES & DEV,PHARM RES GRP EHANOVER NJ 07936 SANDOZ PHARMACEUT CORP,SANDOZ RES INST,TECH RES & DEV,PHARM RES GRP EHANOVER NJ 07936 SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DEPT DRUG METAB & PHARMACOKINET E HANOVER NJ 07936
Titolo Testata:
Pharmaceutical research
fascicolo: 12, volume: 11, anno: 1994,
pagine: 1742 - 1746
SICI:
0724-8741(1994)11:12<1742:EOCMAD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC SOMATOSTATIN ANALOG; SMS 201-995; SMS-201-995; ABSORPTION; TRANSPORT; PEPTIDE; TUMORS;
Keywords:
IONTOPHORESIS; OCTREOTIDE; TRANSDERMAL; PEPTIDE; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
D.T.W. Lau et al., "EFFECT OF CURRENT MAGNITUDE AND DRUG CONCENTRATION ON IONTOPHORETIC DELIVERY OF OCTREOTIDE ACETATE (SANDOSTATIN(R)) IN THE RABBIT", Pharmaceutical research, 11(12), 1994, pp. 1742-1746

Abstract

The effect of current magnitude and drug concentration on transdermaliontophoretic delivery of octreotide acetate (Sandostatin(R)) was examined in the rabbit. Plasma samples were collected over 24 hours and octreotide concentrations were determined by a radioimmunoassay. Without an electrical current, negligible plasma concentrations of octreotide were obtained. Following initiation of iontophoresis, plasma concentrations of octreotide increased rapidly, although did not sustain at aplateau level during the dosing period. Octreotide concentrations declined rapidly after removal of the device. Increasing the electrical current from 50 mu A/cm(2) to 150 mu A/cm(2) yielded a proportional increase in the delivery. Increasing the drug concentration in the devicefrom 2.5 mg/mL to 5 mg/mL resulted in approximately proportional increase in plasma octreotide concentrations; however, further increase inplasma concentrations was not observed for drug concentrations beyond5 mg/mL. Iontophoretic delivery at the conditions which yielded the highest octreotide concentrations in this study (5 mg/mL solution at 150 mu A/cm(2) for 8 hours) yielded an apparent bioavailability (which represents an underestimate of the absolute bioavailability determined when the patches are run to exhaustion) of approximately 8%.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:25:18