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Titolo:
EARLY DETECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN AUSTRALIAN INFANTS AT RISK OF PERINATAL INFECTION AND FACTORS AFFECTINGTRANSMISSION
Autore:
PALASANTHIRAN P; ZIEGLER JB; DWYER DE; ROBERTSON P; LEIGH D; CUNNINGHAM AL;
Indirizzi:
PRINCE WALES CHILDRENS HOSP,HIGH ST RANDWICK NSW 2031 AUSTRALIA PRINCE WALES CHILDRENS HOSP SYDNEY NSW AUSTRALIA PRINCE WALES HOSP SYDNEY NSW AUSTRALIA WESTMEAD HOSP SYDNEY NSW AUSTRALIA
Titolo Testata:
The Pediatric infectious disease journal
fascicolo: 12, volume: 13, anno: 1994,
pagine: 1083 - 1090
SICI:
0891-3668(1994)13:12<1083:EDOHTI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; ENZYMATIC AMPLIFICATION; MATERNAL ANTIBODIES; HIV-1 TRANSMISSION; CHILDREN BORN; DIAGNOSIS; MOTHER; IDENTIFICATION; SEQUENCES; ANTIGEN;
Keywords:
PERINATAL HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; TRANSMISSION RISKS; EARLY DIAGNOSIS; VIRUS ISOLATION; POLYMERASE CHAIN REACTION; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; SERUM IMMUNOGLOBULINS; MATERNAL VIRAL BURDEN; VIRAL PHENOTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
P. Palasanthiran et al., "EARLY DETECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN AUSTRALIAN INFANTS AT RISK OF PERINATAL INFECTION AND FACTORS AFFECTINGTRANSMISSION", The Pediatric infectious disease journal, 13(12), 1994, pp. 1083-1090

Abstract

The earliest, most reliable methods for detecting human immunodeficiency virus type 1 (HIV-1) infection in infants at risk of perinatal HIV-1 and risks for transmission were investigated. Fifteen infants were followed prospectively from birth to age 21 to 48 months. Epidemiologic data on mothers during pregnancy were documented, and maternal proviral load (by quantitative polymerase chain reaction) and viral phenotype by HIV isolation were performed. Infants were assessed clinically and HIV isolation, HIV p24 antigen, polymerase chain reaction and totalserum immunoglobulin determinations were performed. Four infants wereinfected. HIV isolation, HIV p24 antigen and polymerase chain reaction were positive within 3 months in all infected infants (100% sensitivity). False positive rates for a single test were 18, 9 and 9%, respectively. Median age of clearance of maternal antibodies was 13.4 +/- 2.1 months. Serum immunoglobulin G was significantly elevated after 6 months in all 4 infected infants. Advanced maternal age (greater than orequal to 30 years; Fisher's exact test, P > 0.014) was associated with transmission. A trend in higher maternal viral burden was observed among transmitters. Non syncytium-inducing phenotype was present initially in all transmitting mothers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 05:59:06