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Titolo:
COLLAGENASE IN SJOGRENS-SYNDROME
Autore:
KONTTINEN YT; KANGASPUNTA P; LINDY O; TAKAGI M; SORSA T; SEGERBERG M; TSCHESCHE H; EISEN AZ;
Indirizzi:
UNIV HELSINKI,INST BIOMED,DEPT ANAT,POB 9 SF-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT MED CHEM SF-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT PERIODONTOL SF-00014 HELSINKI FINLAND UNIV BIELEFELD,DEPT BIOCHEM W-4800 BIELEFELD GERMANY WASHINGTON UNIV,DEPT DERMATOL ST LOUIS MO 00000
Titolo Testata:
Annals of the Rheumatic Diseases
fascicolo: 12, volume: 53, anno: 1994,
pagine: 836 - 839
SICI:
0003-4967(1994)53:12<836:CIS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN FIBROBLAST COLLAGENASE; HUMAN NEUTROPHIL COLLAGENASE; MATRIX METALLOPROTEINASES; HOMOLOGY; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
Y.T. Konttinen et al., "COLLAGENASE IN SJOGRENS-SYNDROME", Annals of the Rheumatic Diseases, 53(12), 1994, pp. 836-839

Abstract

Objective-To study collagenase production in labial salivary glands in patients with Sjogren's syndrome (SS). Methods-Collagenases were localised in labial salivary glands by immunohistochemistry. Collagenase activity against triple helical type I collagen monomers in stimulatedsaliva was measured using sodium dodecyl sulphate polyacrylamide gel electrophoresis and laser densitometry; tissue inhibitor metalloproteinase (TIMP) was measured by enzyme Linked immunosorbent assay. Results-Cells containing collagenase of matrix metalloproteinase (MMP)-1 typewere more frequent and more intensely staining in SS than in healthy glands. Only SS saliva contained functional enzyme (11.7 (6.8) x 10(-6) IU/1). Cells containing MMP-8 type neutrophil collagenase were not found in situ, which was in accordance with sialochemical findings/doxycycline inhibition studies. TIMP was found in both SS and normal saliva. Conclusions-Fibroblast, but not neutrophil type, collagenase is synthesised, secreted, and subsequently activated, but is not inhibited by TIMP in labial salivary glands or saliva in SS. Collagenase may destroy glandular and salivary duct tissue and perturb factors influencingthe morphogenetic extracellular matrix.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 03:06:14