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Titolo:
SAFETY, IMMUNOGENICITY, AND EFFICACY OF A MALARIA SPOROZOITE VACCINE ADMINISTERED WITH MONOPHOSPHORYL LIPID A, CELL-WALL SKELETON OF MYCOBACTERIA, AND SQUALANE AS ADJUVANT
Autore:
HOFFMAN SL; EDELMAN R; BRYAN JP; SCHNEIDER I; DAVIS J; SEDEGAH M; GORDON D; CHURCH P; GROSS M; SILVERMAN C; HOLLINGDALE M; CLYDE D; SZTEIN M; LOSONSKY G; PAPARELLO S; JONES TR;
Indirizzi:
USN,MED RES INST,MALARIA PROGRAM,MED RES INST ANNEX,12300 WASHINGTON AVE ROCKVILLE MD 20852 UNIV MARYLAND,CTR VACCINE DEV,SCH MED BALTIMORE MD 21201 UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR BETHESDA MD 20814 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL WASHINGTON DC 20307 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL WASHINGTON DC 20307 SMITHKLINE BEECHAM PHARMACEUT,DEPT MACROMOLEC SCI KING OF PRUSSIA PA 19406 NATL NAVAL MED RES INST,DIV INFECT DIS BETHESDA MD 20889 PAN AMER HLTH ORG WASHINGTON DC 00000 BIOMED RES INST ROCKVILLE MD 00000
Titolo Testata:
The American journal of tropical medicine and hygiene
fascicolo: 5, volume: 51, anno: 1994,
pagine: 603 - 612
SICI:
0002-9637(1994)51:5<603:SIAEOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM SPOROZOITES; CIRCUMSPOROZOITE PROTEIN; MURINE MALARIA; ANTIBODIES; HUMANS; INFECTION; REGION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Hoffman et al., "SAFETY, IMMUNOGENICITY, AND EFFICACY OF A MALARIA SPOROZOITE VACCINE ADMINISTERED WITH MONOPHOSPHORYL LIPID A, CELL-WALL SKELETON OF MYCOBACTERIA, AND SQUALANE AS ADJUVANT", The American journal of tropical medicine and hygiene, 51(5), 1994, pp. 603-612

Abstract

A Plasmodium falciparum circumsporozoite protein (PfCSP) recombinant fusion protein, R32NS1(81), formulated with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane (Detox(TM)) was administered to 12 volunteers. One volunteer had malaise and self-limited painful induration at the injection site after the second dose and declined further immunization. The other 11 volunteers tolerated the three doses of 1,230 mu g of vaccine, but most complained of sore arms; in five cases the pain or malaise was severe enough to interfere with work or sleep. Two weeks after the third dose of vaccine, four of the 11 immunized volunteers had greater than or equal to 14 mu g/ml of antibodies to the repeat region of the PfCSP in their serum. Two of these fourvolunteers did not develop P. falciparum parasitemia when challenged by the bite of five mosquitoes carrying P. falciparum sporozoites. Theseven volunteers with lower levels of antibodies and 11 of 11 controls developed parasitemia. These data are consistent with other studies,and indicate that vaccine-induced antibodies against the repeat region of PfCSP can prevent effective sporozoite infection of hepatocytes in humans. The challenge is to improve the immunogenicity of PfCSP-based vaccines, and to develop methods for including PfCSP peptides as components of multitarget malaria vaccines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 12:23:15