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Titolo:
PREDICTING OUTCOME IN MALARIA - CORRELATION BETWEEN RATE OF EXPOSURE TO INFECTED MOSQUITOS AND LEVEL OF PLASMODIUM-FALCIPARUM PARASITEMIA
Autore:
MCELROY PD; BEIER JC; OSTER CN; BEADLE C; SHERWOOD JA; OLOO AJ; HOFFMAN SL;
Indirizzi:
USN,MED RES INST,MALARIA PROGRAM,12300 WASHINGTON AVE ROCKVILLE MD 20852 USN,MED RES INST,MALARIA PROGRAM ROCKVILLE MD 20852 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS BALTIMORE MD 21205 KENYA GOVT MED RES CTR,VECTOR BIOL & CONTROL RES CTR KISUMU KENYA USA,MED RES UNIT NAIROBI KENYA KENYA GOVT MED RES CTR NAIROBI KENYA WALTER REED ARMY INST RES,DEPT IMMUNOL WASHINGTON DC 00000
Titolo Testata:
The American journal of tropical medicine and hygiene
fascicolo: 5, volume: 51, anno: 1994,
pagine: 523 - 532
SICI:
0002-9637(1994)51:5<523:POIM-C>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERMETHRIN-IMPREGNATED CURTAINS; NETS PREVENT MALARIA; TREATED BED NETS; WESTERN KENYA; AREA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
P.D. Mcelroy et al., "PREDICTING OUTCOME IN MALARIA - CORRELATION BETWEEN RATE OF EXPOSURE TO INFECTED MOSQUITOS AND LEVEL OF PLASMODIUM-FALCIPARUM PARASITEMIA", The American journal of tropical medicine and hygiene, 51(5), 1994, pp. 523-532

Abstract

The level of Plasmodium falciparum parasitemia at clinical presentation has repeatedly been shown to correlate with severity of disease. Using data collected in western Kenya over 21 months, we examined associations between exposure variables, especially exposure to infective mosquitoes, and prevalence and density of P. falciparum parasitemia among 1,007 children six months to six years of age. The prevalence of P. falciparum infection was similar at all exposure levels, but there wasa correlation between exposure to sporozoite-infected mosquitoes overthe previous 28-day period, and geometric mean parasite density of each cohort (Spearman rank coefficient = 0.724, P = 0.002). The relativeodds of having a parasite density greater than or equal to 5,000/mu lwas increased almost two-fold among individuals exposed to more than 10 infective bites during the prior 28-day period. Children enrolled during the highest incidence period were 80% more likely to have a density greater than or equal to 5,000/mu l relative to individuals enrolled during periods of lower incidence. The data suggest that measures, such as malaria vaccines, that reduce parasite densities by limiting numbers of sporozoites reaching the liver, or merozoites released from the liver, will reduce malaria-associated morbidity and mortality, even when they do not prevent all infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 11:06:14