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Titolo:
DIMINISHMENT OF CONTRACTIONS ASSOCIATED WITH DEPOLARIZATION-EVOKED ACTIVATION OF CA2+ CHANNELS IN DIABETIC RAT AORTA
Autore:
HATTORI Y; KAWASAKI H; FUKAO M; GANDO S; AKAISHI Y; KANNO M;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PHARMACOL SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Journal of vascular research
fascicolo: 6, volume: 33, anno: 1996,
pagine: 454 - 462
SICI:
1018-1172(1996)33:6<454:DOCAWD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; BAY K-8644; CALCIUM; RESPONSES; AGONIST; ARTERIES; CARDIOMYOPATHY; BAY-K-8644; MELLITUS; MEMBRANE;
Keywords:
DIABETES MELLITUS; VASCULAR CONTRACTION; CA-45(2+) UPTAKE; MEMBRANE DEPOLARIZATION; [H-3] (+)-PN200-110 BINDING; CA2+ CHANNELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
Y. Hattori et al., "DIMINISHMENT OF CONTRACTIONS ASSOCIATED WITH DEPOLARIZATION-EVOKED ACTIVATION OF CA2+ CHANNELS IN DIABETIC RAT AORTA", Journal of vascular research, 33(6), 1996, pp. 454-462

Abstract

Alterations in contractile responses of aortic rings mediated by activation of Ca2+ channels were investigated in rats with streptozotocin-induced diabetes. Eight to 12 weeks of diabetes resulted in a marked decrease in the contractile response of aortic rings to high K+. In contrast, diabetic aortas exhibited significantly greater contractions inresponse to noradrenaline compared to age-matched controls. In the presence of 15 mM K+, the Ca2+ channel agonist Bay K 8644 consistently produced concentration-dependent contractions in control aortas. On theother hand, the half of diabetic aortas did not respond to Bay K 8644. As a result, the contractile response to Bay K 8644 was significantly less in diabetic aortas compared to controls. There was no significant difference in basal Ca-45(2+) uptake between control and diabetic aortas. However, the uptake of Ca-45(2+) induced by high K+ was significantly less in diabetic aortas than in controls, and pretreatment withthe Ca2+ channel antagonist nifedipine abolished both responses. The resting membrane potentials were not significantly different between control and diabetic aortas. Furthermore, no difference was found in the magnitude of depolarization evoked by increasing K+ concentrations between the two groups of tissues. There were no significant differences in the density and the dissociation constant for [H-3]-(+)-PN200-110, a radiolabeled Ca2+ channel antagonist, between aortic membranes from control and diabetic rats. These data indicate that the contractile responses to high K+ and Bay K 8644 are specifically diminished in diabetic aortas. These diminished responses are not due to a difference in the number of Ca2+ channels, but may be related to an alteration in activation of the channels by membrane depolarization.

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Documento generato il 28/11/20 alle ore 21:54:53