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Titolo:
BEHAVIORAL CONSEQUENCES OF NEURAL TRANSPLANTATION
Autore:
DUNNETT SB;
Indirizzi:
UNIV CAMBRIDGE,CAMBRIDGE CTR BRAIN REPAIR,DOWNING ST CAMBRIDGE CB2 3EB ENGLAND UNIV CAMBRIDGE,DEPT EXPTL PSYCHOL CAMBRIDGE CB2 3EB ENGLAND
Titolo Testata:
Journal of neurology
fascicolo: 1, volume: 242, anno: 1994, supplemento:, 1
pagine: 190000043 - 190000053
SICI:
0340-5354(1994)242:1<190000043:BCONT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; FETAL DOPAMINE NEURONS; RECOVERY FOLLOWING TRANSPLANTATION; PARKINSONS-DISEASE; SUBSTANTIA NIGRA; 6-OHDA LESIONS; NIGROSTRIATAL PATHWAY; STRIATAL GRAFTS; CAUDATE-NUCLEUS; AGED RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
98
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Dunnett, "BEHAVIORAL CONSEQUENCES OF NEURAL TRANSPLANTATION", Journal of neurology, 242(1), 1994, pp. 190000043-190000053

Abstract

Neural grafts can reverse many functional deficits associated with brain damage, whether of traumatic, toxic, neurodegenerative or genetic origin. In some model systems recovery can be partial or complete, whereas in others the grafts have limited effects or may actually cause further dysfunction. In order to devise rational and effective transplantation strategies it is necessary to understand the mechanisms by which grafts exert their functional effects. Several alternatives have been proposed, and these include non-specific consequences of surgery, acute diffuse neurotrophic and growth mechanisms, chronic diffuse release of deficient neurochemicals, bridging tissues for host regeneration, diffuse reinnervation of the host brain, and reciprocal graft-host reconnection. These alternative mechanisms are not necessarily exclusive in any particular situation, and all have been seen to apply in different model systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:30:13