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Titolo:
OUTCOME OF PERINATAL HEPATITIS-B VIRUS EXPOSURE IS DEPENDENT ON MATERNAL VIRUS LOAD
Autore:
BURK RD; HWANG LY; HO GYF; SHAFRITZ DA; BEASLEY RP;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,MARION BESSIN LIVER RES CTR,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT CELL BIOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT EPIDEMIOL & SOCIAL MED BRONX NY 10461 UNIV TEXAS,HLTH SCI CTR,CTR INFECT DIS,SCH PUBL HLTH HOUSTON TX 00000 UNIV TEXAS,HLTH SCI CTR,GRAD SCH BIOMED SCI HOUSTON TX 00000 AMER MED RES CTR TAIPEI TAIWAN
Titolo Testata:
The Journal of infectious diseases
fascicolo: 6, volume: 170, anno: 1994,
pagine: 1418 - 1423
SICI:
0022-1899(1994)170:6<1418:OOPHVE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM HBV-DNA; E-ANTIGEN; SURFACE-ANTIGEN; VERTICAL TRANSMISSION; HEPATOCELLULAR-CARCINOMA; MOLECULAR HYBRIDIZATION; DEOXYRIBONUCLEIC-ACID; HBSAG-CARRIERS; LIVER-DISEASE; HBEAG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Burk et al., "OUTCOME OF PERINATAL HEPATITIS-B VIRUS EXPOSURE IS DEPENDENT ON MATERNAL VIRUS LOAD", The Journal of infectious diseases, 170(6), 1994, pp. 1418-1423

Abstract

To evaluate the role of maternal hepatitis B virus (HBV) DNA levels in perinatal infection, two nested case-control studies were done within a cohort of 773 hepatitis B surface antigen (HBsAg)-positive Taiwanese women and their infants. As serum HBV DNA levels increased from <0.005 to greater than or equal to 1.4 ng/mL among the hepatitis B e antigen (HBeAg)-positive mothers, the odds ratio (OR) for having a persistently infected infant increased from 1.0 to 147.0 (P for trend <.001). Among HBeAg-negative mothers, the OR for having a persistently infected infant was 19.2 (95% confidence interval, 2.3-176.6) in mothers with high versus low levels of serum HBV DNA. A logistic regression analysis identified maternal HBV DNA to be a stronger independent predictorof persistent infection than HBeAg status. Thus, perinatal exposure to high levels of maternal HBV DNA is the most important determinant ofinfection outcome in the infant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:32:06