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Titolo:
RISK-FACTORS FOR SQUAMOUS INTRAEPITHELIAL LESIONS ON PAP SMEAR IN WOMEN AT RISK FOR HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
Autore:
KLEIN RS; HO GYF; VERMUND SH; FLEMING I; BURK RD;
Indirizzi:
MONTEFIORE MED CTR,DEPT MED,AIDS RES PROGRAM,111 E 210TH ST BRONX NY 10467 MONTEFIORE MED CTR,DEPT EPIDEMIOL & SOCIAL MED BRONX NY 10467 MONTEFIORE MED CTR,DEPT PEDIAT BRONX NY 10467 MONTEFIORE MED CTR,DEPT MICROBIOL & IMMUNOL BRONX NY 10467 MONTEFIORE MED CTR,DEPT OBSTET & GYNECOL BRONX NY 10467 ALBERT EINSTEIN COLL MED BRONX NY 10467
Titolo Testata:
The Journal of infectious diseases
fascicolo: 6, volume: 170, anno: 1994,
pagine: 1404 - 1409
SICI:
0022-1899(1994)170:6<1404:RFSILO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PAPILLOMAVIRUS INFECTION; GENITAL HUMAN PAPILLOMAVIRUS; CERVICAL NEOPLASIA; HIV-INFECTION; IMMUNOSUPPRESSION; ABNORMALITIES; WARTS; RECIPIENTS; DISEASE; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Klein et al., "RISK-FACTORS FOR SQUAMOUS INTRAEPITHELIAL LESIONS ON PAP SMEAR IN WOMEN AT RISK FOR HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION", The Journal of infectious diseases, 170(6), 1994, pp. 1404-1409

Abstract

To determine risk factors for squamous intraepithelial lesions (SIL) on Pap smear, 253 women at risk for human immunodeficiency virus (HIV)infection had Pap smear, HIV antibody testing, CD4(+) cell measurements, and human papillomavirus (HPV) genome detection by Southern blot hybridization. Associated with SIL (P < .05) on univariate analysis were genital HPV (SIL prevalence in HPV-positive subjects, 36.3%; odds ratio [OR], 9.3; 95% confidence interval [CI], 4.2-20.3) and HIV infection (SIL prevalence in seropositive subjects, 21.9%; OR, 2.5; 95% CI, 1.2-5.1). No demographic or behavioral variables were associated with risk for SIL. Multivariate analyses identified genital HPV infection (OR, 6.78; 95% CI, 2.9-15.7), detection of known high-risk HPV types (OR, 11.8; 95% CI, 4.1-34.1), strong HPV Southern blot signal strength (OR, 10.8; 95% CI, 3.5-33.7), and severe HIV-related immunosuppression (OR, 3.1; 95% CI, 1.04-9.5) as independent risk factors associated withSIL. Thus, severe immunosuppression due to HIV infection increases the risk for SIL mediated by HPV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 08:01:14