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Titolo:
PROPRANOLOL PLUS ISOSORBIDE-5-MONONITRATE FOR PORTAL-HYPERTENSION IN CIRRHOSIS - LONG-TERM HEMODYNAMIC AND RENAL EFFECTS
Autore:
MORILLAS RM; PLANAS R; CABRE E; GALAN A; QUER JC; FEU F; PAGAN JCG; BOSCH J; GASSULL MA;
Indirizzi:
HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL,CARRETERA CANYET S-N E-08916 BADALONA SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL E-08916 BADALONA SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT BIOCHEM E-08916 BADALONA SPAIN HOSP CLIN BARCELONA,LIVER UNIT E-08036 BARCELONA SPAIN
Titolo Testata:
Hepatology
fascicolo: 6, volume: 20, anno: 1994,
pagine: 1502 - 1508
SICI:
0270-9139(1994)20:6<1502:PPIFPI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; VENOUS-BLOOD FLOW; ISOSORBIDE DINITRATE; ALCOHOLIC CIRRHOSIS; VARICEAL HEMORRHAGE; ESOPHAGEAL-VARICES; BETA-BLOCKADE; PREVENTION; SCLEROTHERAPY; ASCITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Morillas et al., "PROPRANOLOL PLUS ISOSORBIDE-5-MONONITRATE FOR PORTAL-HYPERTENSION IN CIRRHOSIS - LONG-TERM HEMODYNAMIC AND RENAL EFFECTS", Hepatology, 20(6), 1994, pp. 1502-1508

Abstract

The effect on kidney function, vasoactive systems and ascites outcomeof long-term treatment with propranolol plus isosorbide-5-mononitrate, a combined therapy proven more effective than propranolol alone in decreasing portal pressure in the cirrhotic patient, is unknown. Thirtycirrhotic patients who survived acute variceal bleeding and were treated with propranolol plus isosorbide-5-mononitrate were studied. Portal and systemic hemodynamics (n = 15), inulin clearance, free water clearance, plasma renin activity, aldosterone concentration and prostaglandin E(2) excretion (n = 20) were measured before and after 3 mo of treatment. In addition, data on ascites outcome in the entire series after a mean follow-up of 9.6 mo were compared with those of 30 patients undergoing elective sclerotherapy and with those of 30 patients treated with propranolol alone matched for age, sex, presence of ascites, Child-Pugh class and mean follow-up length included in other randomized controlled trials. Combined therapy significantly decreased the hepatic venous pressure gradient and azygos blood how. In addition, no changes in inulin clearance, free water clearance, plasma renin activity, aldosterone concentration and prostaglandin E(2) excretion occurred, despite a mild decrease in mean arterial pressure. Moreover, no differences among the three groups of patients studied in ascites outcome werefound. These results suggest that long-term treatment with pro. pranolol plus isosorbide-5-mononitrate does not impair kidney function, vasoactive systems or ascites outcome in cirrhotic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:13:10