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Titolo:
CATIONIC PROTEIN-INDUCED SENSORY NERVE ACTIVATION - ROLE OF SUBSTANCE-P IN AIRWAY HYPERRESPONSIVENESS AND PLASMA-PROTEIN EXTRAVASATION
Autore:
COYLE AJ; PERRETTI F; MANZINI S; IRVIN CG;
Indirizzi:
CIBA GEIGY AG,DEPT ALLERGY & ASTHMA CH-4002 BASEL SWITZERLAND UNIV COLORADO,HLTH SCI CTR,DEPT MED,DIV PULM SCI DENVER CO 80206 NATL JEWISH CTR IMMUNOL & RESP MED DENVER CO 80206 MALESCI PHARMACEUT FLORENCE ITALY MENARINI SUD I-00040 POMEZIA ITALY
Titolo Testata:
The Journal of clinical investigation
fascicolo: 6, volume: 94, anno: 1994,
pagine: 2301 - 2306
SICI:
0021-9738(1994)94:6<2301:CPSNA->2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR BASIC-PROTEIN; INDUCED BRONCHIAL HYPERRESPONSIVENESS; HUMAN EOSINOPHIL GRANULE; GUINEA-PIG TRACHEA; NEUTRAL ENDOPEPTIDASE; INDUCED BRONCHOCONSTRICTION; SMOOTH-MUSCLE; CAPSAICIN; TACHYKININS; ANTAGONIST;
Keywords:
CATIONIC PROTEINS; AIRWAY HYPERRESPONSIVENESS; SUBSTANCE P; TACHYKININS; PLASMA EXTRAVASATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Coyle et al., "CATIONIC PROTEIN-INDUCED SENSORY NERVE ACTIVATION - ROLE OF SUBSTANCE-P IN AIRWAY HYPERRESPONSIVENESS AND PLASMA-PROTEIN EXTRAVASATION", The Journal of clinical investigation, 94(6), 1994, pp. 2301-2306

Abstract

We have previously reported that human eosinophil granule major basicprotein and synthetic cationic proteins such as poly-L-arginine and poly-L-lysine, can increase airway responsiveness in vivo. In the present study, we have investigated whether activation of sensory C-fibers is important in this phenomenon. Dose-response curves to methacholine were constructed before and 1 h after intratracheal instillation of poly-L-lysine in anaesthetized spontaneously breathing rats, and the concentration of methacholine required to induce a doubling in total lungresistance was calculated. Poly-L-lysine induced a fivefold increase in airway responsiveness, which was inhibited by neonatal capsaicin treatment and potentiated by phosphoramidon (100 mu g/ml). Furthermore, pretreatment with either CP, 96-345, or RP-67580 two selective NK-1 receptor antagonists inhibited poly-L-lysine-induced airway hyperresponsiveness and plasma protein extravasation. In vitro, cationic proteins stimulated the release of calcitonin gene-related peptidelike immunoreactivity from perfused slices of the main bronchi. Our results demonstrate that cationic proteins can activate sensory C-fibers in the airways, an effect which is important in the subsequent development of airway hyperresponsiveness and plasma protein extravasation. Cationic proteins may therefore function as a link between inflammatory cell accumulation and sensory nerve activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:32:30