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Titolo:
DISULFIRAM-INDUCED HEPATITIS - REPORT OF 4 CASES AND REVIEW OF THE LITERATURE
Autore:
FORNS X; CABALLERIA J; BRUGUERA M; SALMERON JM; VILELLA A; MAS A; PARES A; RODES J;
Indirizzi:
HOSP CLIN BARCELONA,LIVER UNIT,VILLARROEL 170 E-08036 BARCELONA SPAIN HOSP CLIN BARCELONA,LIVER UNIT E-08036 BARCELONA SPAIN
Titolo Testata:
Journal of hepatology
fascicolo: 5, volume: 21, anno: 1994,
pagine: 853 - 857
SICI:
0168-8278(1994)21:5<853:DH-RO4>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FULMINANT-HEPATITIS; HEPATOTOXICITY; ALCOHOLISM;
Keywords:
ACUTE HEPATITIS; ALCOHOLISM THERAPY; HEPATOTOXICITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
X. Forns et al., "DISULFIRAM-INDUCED HEPATITIS - REPORT OF 4 CASES AND REVIEW OF THE LITERATURE", Journal of hepatology, 21(5), 1994, pp. 853-857

Abstract

Liver test abnormalities following disulfiram therapy are common. However, overt disulfiram-induced hepatitis is rare but has a high mortality rate, specially when the etiologic role of disulfiram is not suspected and treatment is not discontinued. We report four cases of disulfiram-induced acute hepatitis with different degrees of severity and review the cases reported in the literature. The clinical spectrum of disulfiram hepatotoxicity ranges from minor elevation of serum aminotransferases to fulminant hepatitis. Although some patients with disulfiram-induced hepatitis have manifestations of hypersensitivity, recent clinical and experimental data suggest that disulfiram hepatotoxicity isproduced by the accumulation of toxic metabolites. (C) Journal of Hepatology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:26:56