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Titolo:
PREVENTION OF RELAPSE IN PATIENTS WITH CHRONIC NON-A, NON-B C HEPATITIS WHO RESPOND TO ALPHA-INTERFERON - A CONTROLLED MULTICENTER TRIAL OFLOW-DOSE MAINTENANCE THERAPY/
Autore:
VALLA D; BABANY G; OUZAN D; TREPO C; BOURLIERE M; CALES P; PAYEN JL; COUZIGOU P; BUFFET C; MICHEL P; VEYRAC M; BERCOFF E; LEVY VG; PARIS JC; GRANGE JD; VALLA A; FISCHER D; EUGENE C; DENIS J; VOIGT JJ; FABRE M; LECHARPENTIER Y; OPOLON P; VALARD S; GAUTHIER A; PASCAL JP; PELLETIER G; COLIN R; MICHEL H; BOURREILLE J; GUIVARCH P; MATHIEUCHANDELIER C; BODIN F; LABAYLE D; DAO T; ANCIAUX ML;
Indirizzi:
GRP HOSP PITIE SALPETRIERE,SERV HEPATOGASTROENTEROL,47 BLVD HOP F-75013 PARIS FRANCE HOP ARNAUD TZANK,DEPT HEPATOGASTROENTEROL LYON FRANCE HOP ST LAURENT VAR,DEPT HEPATOGASTROENTEROL LYON FRANCE HOP HOTEL DIEU,DEPT HEPATOGASTROENTEROL LYON FRANCE HOP LA CONCEPT MARSEILLE FRANCE HOP HAUT LEVEQUE PESSAC FRANCE ROCHE PROD LTD NEUILLY SUR SEINE FRANCE HOP BICETRE LE KREMLIN BICETR FRANCE HOP CHARLES NICOLLE F-76031 ROUEN FRANCE HOP ST ELOI MONTPELLIER FRANCE HOP BOIS GUILLAUME ROUEN FRANCE HOP ST ANTOINE F-75571 PARIS FRANCE HOP HURIEZ LILLE FRANCE HOP TENON F-75970 PARIS FRANCE HOP COTE NACRE CAEN FRANCE HOP LOUISE MICHEL EVRY FRANCE CTR HOSP INTERCOMMUNAL POISSY FRANCE CTR HOSP INTERCOMMINAL GILLES CORBEIL CORBEIL ESSONNES FRANCE HOP PURPAN,DEPT PATHOL TOULOUSE FRANCE
Titolo Testata:
Journal of hepatology
fascicolo: 5, volume: 21, anno: 1994,
pagine: 774 - 778
SICI:
0168-8278(1994)21:5<774:PORIPW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-B HEPATITIS; RECEPTOR EXPRESSION; VIRUS-INFECTION; PLACEBO; ALFA;
Keywords:
CHRONIC VIRAL HEPATITIS C; INTERFERON; LIVER BIOPSY; MAINTENANCE THERAPY; RANDOMIZED CONTROLLED TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
D. Valla et al., "PREVENTION OF RELAPSE IN PATIENTS WITH CHRONIC NON-A, NON-B C HEPATITIS WHO RESPOND TO ALPHA-INTERFERON - A CONTROLLED MULTICENTER TRIAL OFLOW-DOSE MAINTENANCE THERAPY/", Journal of hepatology, 21(5), 1994, pp. 774-778

Abstract

We tested the efficacy of maintenance treatment with alpha-2a interferon, 1 megaunit thrice weekly for 6 months, in preventing relapse of non-A, non-B/C hepatitis in remission after treatment with alpha interferon given thrice weekly according to the following dose schedule: 3 megaunits for 3 months, 2 megaunits for 2 months and 1 megaunit for 1 month. Fifty-three patients with hepatitis C in remission were randomlyallocated to a treatment group (n=26) or a control group (n=27). A relapse (aminotransferase activity >1.5 times the upper limit of normal)occurred in 46% of the controls and 35% of the treated patients (NS). Maintenance treatment had no significant influence on histopathologicchanges evaluated by three independent observers: in both groups the overall score for histologic lesions improved between the initiation of interferon therapy and the end of the study. We conclude that relapses in patients with non-A, non-B/C hepatitis in remission after treatment with alpha interferon at tapering doses are not prevented by maintenance therapy with low-dose alpha interferon. (C) Journal of Hepatology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:12:14