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Titolo:
TIANEPTINE - AN INSTANCE OF DRUG-INDUCED HEPATOTOXICITY PREDICTED BY PROSPECTIVE EXPERIMENTAL STUDIES
Autore:
LEBRICQUIR Y; LARREY D; BLANC P; PAGEAUX GP; MICHEL H;
Indirizzi:
HOP ST ELOI,SERV HEPATOGASTROENTEROL,AVE BERTIN SANS F-34059 MONTPELLIER FRANCE HOP ST ELOI,SERV HEPATOGASTROENTEROL F-34059 MONTPELLIER FRANCE
Titolo Testata:
Journal of hepatology
fascicolo: 5, volume: 21, anno: 1994,
pagine: 771 - 773
SICI:
0168-8278(1994)21:5<771:T-AIOD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRICYCLIC ANTIDEPRESSANT AMINEPTINE; INVITRO COVALENT BINDING; METABOLIC-ACTIVATION; MITOCHONDRIAL OXIDATION; FATTY-ACIDS; LIVER; MICE;
Keywords:
MICROVESICULAR STEATOSIS; REACTIVE METABOLITES; TIANEPTINE HEPATOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
Y. Lebricquir et al., "TIANEPTINE - AN INSTANCE OF DRUG-INDUCED HEPATOTOXICITY PREDICTED BY PROSPECTIVE EXPERIMENTAL STUDIES", Journal of hepatology, 21(5), 1994, pp. 771-773

Abstract

We report the case of a patient who developed acute hepatitis after taking tianeptine, a new tricyclic antidepressant, for 8 weeks. Hepatitis exhibited cholangitis-like clinical features and was associated with hypersensitivity manifestations suggestive of an immune-allergic mechanism. Histological examination showed microvesicular steatosis. The discontinuation of tianeptine administration was followed by complete recovery. Immunoallergic hepatitis and microvesicular steatosis were predicted 2 years ago from prospective experimental studies prompted bythe similarity of the chemical structures of tianeptine and amineptine, another tricyclic antidepressant, well-known for its hepatotoxicity. Experimentally, tianeptine has been found to be oxidized into reactive metabolites in several rodents and human liver and to produce microvesicular steatosis probably through inhibition of mitochondrial beta-oxidation of fatty acid in mice. This case illustrates the value of prospectively assessing potential hepatotoxicity mechanisms for new compounds chemically related to drugs already known to be hepatotoxic. (C)Journal of Hepatology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:31:55