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Titolo:
RANDOMIZED TRIAL OF A CHLORHEXIDINE MOUTHWASH FOR ALLEVIATION OF RADIATION-INDUCED MUCOSITIS
Autore:
FOOTE RL; LOPRINZI CL; FRANK AR; OFALLON JR; GULAVITA S; TEWFIK HH; RYAN MA; EARLE JM; NOVOTNY P;
Indirizzi:
MAYO CLIN & MAYO FDN,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN ROCHESTER MN 55905 CREIGHTON UNIV,MED CTR,NEBRASKA ONCOL GRP OMAHA NE 00000 THUNDER BAY REG CANC CTR THUNDER BAY ON CANADA DULUTH COMMUNITY CLIN ONCOL PROGRAM DULUTH MN 00000 CEDAR RAPIDS ONCOL PROJECT COMMUNITY CLIN ONCOL P CEDAR RAPIDS IA 00000 IOWA ONCOL RES ASSOC COMMUNITY CLIN ONCOL PROGRAM DES MOINES IA 00000
Titolo Testata:
Journal of clinical oncology
fascicolo: 12, volume: 12, anno: 1994,
pagine: 2630 - 2633
SICI:
0732-183X(1994)12:12<2630:RTOACM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; LOCAL-CONTROL; SPLIT-COURSE; IRRADIATION MUCOSITIS; ORAL MUCOSITIS; TREATMENT TIME; NECK-CANCER; RADIOTHERAPY; HEAD; REPOPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Foote et al., "RANDOMIZED TRIAL OF A CHLORHEXIDINE MOUTHWASH FOR ALLEVIATION OF RADIATION-INDUCED MUCOSITIS", Journal of clinical oncology, 12(12), 1994, pp. 2630-2633

Abstract

Purpose: To determine whether a chlorhexidine mouthwash could alleviate radiation-induced oral mucositis. Patients and Methods: Patients scheduled to receive radiation therapy to include greater than one thirdof the oral cavity mucosa were selected for study. Following stratification, they were randomized in a double-blind manner to receive a chlorhexidine mouthwash or a placebo mouthwash. Both groups were then similarly evaluated for mucositis and mouthwash toxicity. Results: Twenty-five patients were randomized to receive chlorhexidine mouthwash, while 27 received the placebo mouthwash. Treatment arms were well balanced. There was a trend for more mucositis and there was substantially more toxicity leg, mouthwash-induced discomfort, taste alteration, and teeth staining) on the chlorhexidine arm. Conclusion: In contrast to the prestudy hypothesis that a chlorhexidine mouthwash might provide benefit for patients receiving radiation therapy to the oral mucosa, thisstudy provides strong evidence suggesting that a chlorhexidine mouthwash is detrimental in this clinical situation. (C) 1994 by American Society of Clinical Oncology.

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Documento generato il 26/11/20 alle ore 07:10:45