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Titolo:
ACUTE COCAINE ADMINISTRATION INDUCES VENTRICULAR REGIONAL WALL-MOTIONAND ULTRASTRUCTURAL ABNORMALITIES IN AN ANESTHETIZED RABBIT MODEL
Autore:
GARDIN JM; WONG N; ALKER K; HALE SL; PAYNTER J; KNOLL M; JAMISON B; PATTERSON M; KLONER RA;
Indirizzi:
HOSP GOOD SAMARITAN,INST HEART,RES DEPT,616 S WITMER ST LOS ANGELES CA 90017 HOSP GOOD SAMARITAN,INST HEART,RES DEPT LOS ANGELES CA 90017 UNIV CALIF IRVINE,IRVINE MED CTR,DIV CARDIOL ORANGE CA 92668 UNIV SO CALIF,CARDIOL SECT LOS ANGELES CA 00000
Titolo Testata:
The American heart journal
fascicolo: 6, volume: 128, anno: 1994,
parte:, 1
pagine: 1117 - 1129
SICI:
0002-8703(1994)128:6<1117:ACAIVR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-ISCHEMIA; CONSCIOUS DOGS; BLOOD-FLOW; HEART; VASOCONSTRICTION; ECHOCARDIOGRAPHY; INTRANASAL; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Gardin et al., "ACUTE COCAINE ADMINISTRATION INDUCES VENTRICULAR REGIONAL WALL-MOTIONAND ULTRASTRUCTURAL ABNORMALITIES IN AN ANESTHETIZED RABBIT MODEL", The American heart journal, 128(6), 1994, pp. 1117-1129

Abstract

Whether acute doses of cocaine can induce left ventricular (LV) regional wall motion abnormalities in animals with otherwise normal coronary arteries is unknown. We studied rabbits receiving constant cocaine infusions (group I: 0.025 to 1.5 mg/kg/min, n = 10), multiple cocaine boluses (group II: 3-5 mg/kg each bolus, n = 10), or saline (group III;n = 8). In group I rabbits, short-axis LV area and diameter increasedby 15% to 40% at 60 minutes compared to baseline and to controls (p <0.01), but percentage of global area fractional shortening was unchanged. Eight rabbits in each of groups I and II, but no controls, developed LV regional wall motion abnormalities as detected by echocardiography: 15 (7 hypokinesis and 8 akinesis or dyskinesis) in the anteroseptal and 2 (hypokinesis) in the posterior LV wall. Among rabbits showingLV wall motion abnormalities, anteroseptal fractional shortening and % area reduction averaged >20% less (p = 0.03 for area reduction) at 30 minutes versus controls. Only 50% of group I or II rabbits with LV anteroseptal wall motion abnormalities had intraventricular conduction disturbances. Radioactive microsphere flow studies (n = 6) 1 minute after a 4 mg/kg cocaine bolus revealed an equivalent decrease (10% to 20%, average) in septal and LV free wall perfusion (p value not significant). Electron microscopy revealed myocardial cell contraction band necrosis in 3 and sarcoplasmic reticular edema in 7 of 10 cocaine rabbits (unrelated to dose). We conclude that acute cocaine administration in rabbits frequently produces LV anteroseptal wall motion abnormalities even in the absence of differentially decreased perfusion or intraventricular conduction disturbances and produces ultrastructural abnormalities of the myocytes. These findings suggest a direct, nonuniform effect of cocaine on the LV myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:14:08