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Titolo:
PARENTAL ORIGIN OF DIABETES-ASSOCIATED HLA TYPES IN SIBLING PAIRS WITH TYPE-I DIABETES
Autore:
BAIN SC; ROWE BR; BARNETT AH; TODD JA;
Indirizzi:
UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG OXFORD OX3 9DU ENGLAND UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG OXFORD OX3 9DU ENGLAND UNIV BIRMINGHAM BIRMINGHAM W MIDLANDS ENGLAND BIRMINGHAM HEARTLANDS HOSP,DEPT MED BIRMINGHAM B9 5ST W MIDLANDS ENGLAND
Titolo Testata:
Diabetes
fascicolo: 12, volume: 43, anno: 1994,
pagine: 1462 - 1468
SICI:
0012-1797(1994)43:12<1462:POODHT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREFERENTIAL TRANSMISSION; MELLITUS; SUSCEPTIBILITY; IDDM; RISK; DISORDERS; FAMILIES; ANTIGENS; ALLELES; REGION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S.C. Bain et al., "PARENTAL ORIGIN OF DIABETES-ASSOCIATED HLA TYPES IN SIBLING PAIRS WITH TYPE-I DIABETES", Diabetes, 43(12), 1994, pp. 1462-1468

Abstract

Genetic susceptibility to type I diabetes is partly determined by genes located in the human leukocyte antigen (HLA) region on chromosome 6. It has been claimed that the transmission of HLA-encoded susceptibility is influenced by parental sex. Fathers are reported to transmit HLA-DR4 haplotypes more frequently to their diabetic offspring than mothers. More recently, it has been suggested that the presence of HLA-DR4in a mother may influence susceptibility in her offspring, even when it is not inherited. We have analyzed 172 multiplex diabetic pedigreesfrom the U.K. and find no evidence to support an important effect of parental sex on the inheritance of HLA-encoded susceptibility. Examination of a further 110 pedigrees hom the U.S. supports this finding. These results have important implications for strategies involving genetic screening for type I diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:41:04