Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHARACTERIZATION OF INDUCED PULPAL HYPOXIA USING H-3 MISONIDAZOLE
Autore:
BAUMGARDNER KR; OSBORNE JW; WALTON RE; BORN JL;
Indirizzi:
713 EASTMOOR DR IOWA CITY IA 52246 UNIV IOWA,DEPT ENDODONT IOWA CITY IA 52242 UNIV IOWA,COLL DENT,DEPT ENDODONT IOWA CITY IA 52242 UNIV IOWA,COLL MORPHOL,RADIAT BIOL PROGRAM IOWA CITY IA 52242
Titolo Testata:
Journal of endodontics
fascicolo: 12, volume: 20, anno: 1994,
pagine: 585 - 588
SICI:
0099-2399(1994)20:12<585:COIPHU>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MISONIDAZOLE BINDING; MOUSE-TISSUES; BIOREDUCTIVE DRUGS; HYPOBARIC HYPOXIA; TUMOR HYPOXIA; CYTO-TOXICITY; SIDE-CHAIN; CELLS; METABOLISM; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
K.R. Baumgardner et al., "CHARACTERIZATION OF INDUCED PULPAL HYPOXIA USING H-3 MISONIDAZOLE", Journal of endodontics, 20(12), 1994, pp. 585-588

Abstract

Tritiated misonidazole (H-3-MISO) is a bioreductively activated marker which preferentially binds to cells with decreased oxygen tension (hypoxia). Detection of hypoxia may be an important indicator of metabolic imbalance. For H-3-MISO to be functional as a marker, normal oxygen(normoxic) levels must be distinguishable from increased hypoxic retention. This investigation characterized retention of H-3-MISO in: (a) normoxic pulp, (b) induced hypoxic pulp, and (c) reoxygenated hypoxic pulp. Rats were injected intraperitoneally with either H-3-MISO, unlabeled MISO, or saline, then divided into normoxic and hypoxic groups with appropriate controls. Normoxic animals were maintained at ambient pressure. Hypoxia was induced by placing animals in a hypobaric chamberat 0.5 atm. Pulps were then removed and prepared for liquid scintillation counting. Hypoxic pulps retained significantly more H-3-MISO thannormoxic pulps (analysis of variance, p = 0.001). Hypoxic H-3-MISO retention was unaffected by subsequent, transient tissue reoxygenation. H-3-MISO detects changes in pulpal oxygen status that deviate from normal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:25:58