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Titolo:
ACCUMULATION OF APOLIPOPROTEIN-E AND BETA-AMYLOID-LIKE PROTEIN IN A TRACE OF THE HIPPOCAMPAL CA1 PYRAMIDAL CELL LAYER AFTER ISCHEMIC DELAYED NEURONAL DEATH
Autore:
ISHIMARU H; ISHIKAWA K; HAGA S; SHOJI M; OHE Y; HAGA C; SASAKI A; TAKASHASHI A; MARUYAMA Y;
Indirizzi:
GUNMA UNIV,SCH MED,DEPT NEUROPHARMACOL TSUMURA,3-39-22 SHOWA MACHI MAEBASHI GUMMA 371 JAPAN GUNMA UNIV,SCH MED,DEPT MOL PHYSIOL,INST MOL & CELLULAR REGULAT MAEBASHI GUMMA 371 JAPAN GUNMA UNIV,SCH MED,DEPT NEUROL MAEBASHI GUMMA 371 JAPAN GUNMA UNIV,SCH MED,DEPT PATHOL MAEBASHI GUMMA 371 JAPAN PSYCHIAT RES INST TOKYO,DEPT NEUROPATHOL TOKYO 156 JAPAN
Titolo Testata:
NeuroReport
fascicolo: 18, volume: 7, anno: 1996,
pagine: 3063 - 3067
SICI:
0959-4965(1996)7:18<3063:AOAABP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; SENILE PLAQUES; ISCHEMIA; BINDING; PRECURSOR; PEPTIDE; BRAIN;
Keywords:
ISCHEMIA; DELAYED NEURONAL DEATH; APOLIPOPROTEIN E; BETA-AMYLOID (A-BETA); BETA-AMYLOID PROTEIN PRECURSOR (APP); ASTROCYTE; HIPPOCAMPUS; GERBIL; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Ishimaru et al., "ACCUMULATION OF APOLIPOPROTEIN-E AND BETA-AMYLOID-LIKE PROTEIN IN A TRACE OF THE HIPPOCAMPAL CA1 PYRAMIDAL CELL LAYER AFTER ISCHEMIC DELAYED NEURONAL DEATH", NeuroReport, 7(18), 1996, pp. 3063-3067

Abstract

We found that apolipoprotein E (apo E) accumulates in a trace of the hippocampal CA1 pyramidal cell layer within 6 months after 5 min ischaemia. Intense methenamine-silver (M-S) stainings were seen in the entire CA1 subfield 3 months after ischaemia. The M-S staining pattern mayimply the appearance of soluble A beta-like proteins. The apo E-positive trace was also positively stained with anti-beta-amyloid (A beta) protein antibodies, but not with anti-beta-amyloid protein precursor (APP) antibodies. These results suggest that A beta-like protein accumulates in ischaemic brain after neuronal cell death. Adjacent reactive astrocytes showed both apo E- and A beta-immunoreactivities. These astrocytes may be involved in the clearance of apo E- and A beta-positivematerial. We presume that the coincident distribution pattern for apoE- and A beta-immunoreactivity implies formation of the insoluble andstable A beta-apo E complex which is known to exist in the brain of individuals with Alzheimer's disease. The ischaemic model may he usefulin studying apo E and A beta deposition in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:15:54