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Titolo:
PHASIC HYPERACTIVITY OF THE HPA AXIS RESULTING FROM CHRONIC CENTRAL IL-2 ADMINISTRATION
Autore:
HANISCH UK; ROWE W; VANROSSUM D; MEANEY MJ; QUIRION R;
Indirizzi:
MAX DELBRUCK CTR MOL MED,ROBERT ROSSLE STR 10 D-13122 BERLIN GERMANY MCGILL UNIV,DOUGLAS HOSP,RES CTR VERDUN PQ H4H 1R3 CANADA MCGILL UNIV,DEPT PSYCHIAT VERDUN PQ H4H 1R3 CANADA MCGILL UNIV,DEPT NEUROL NEUROSURG VERDUN PQ H4H 1R3 CANADA MAX PLANCK INST BRAIN RES,DEPT NEUROCHEM D-60528 FRANKFURT GERMANY
Titolo Testata:
NeuroReport
fascicolo: 18, volume: 7, anno: 1996,
pagine: 2883 - 2888
SICI:
0959-4965(1996)7:18<2883:PHOTHA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; NERVOUS-SYSTEM; INTERLEUKIN-2; CYTOKINES; RELEASE; HYPOTHALAMUS; INDUCTION; SECRETION; AMYGDALA;
Keywords:
CYTOKINES; HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS; NEURAL-IMMUNE INTERACTION; NEUROENDOCRINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
U.K. Hanisch et al., "PHASIC HYPERACTIVITY OF THE HPA AXIS RESULTING FROM CHRONIC CENTRAL IL-2 ADMINISTRATION", NeuroReport, 7(18), 1996, pp. 2883-2888

Abstract

INTRACEREBROVENTRICULAR infusion of interleukin-2 (IL-2, 15 U h(-1) for 14 days) chronically activated the hypothalamic-pituitary-adrenocortical (HPA) axis in rats. IL-2 induced increases in plasma levels of adrenocorticotropic hormone (ACTH, up to two-fold) and corticosterone (up to four-fold) compared with controls. Continuously elevated brain levels of IL-2 did not lead to a persistent HPA activation, but resulted in (two) periods of hormonal hypersecretion. ACTH and corticosteronelevels were elevated between days 3 and 5, with changes in corticosterone preceding those of ACTH. Concentrations of corticosterone, but not of ACTH, increased again on day 11. Underscoring its importance as aneuroendocrine regulator, this study reveals that, in addition to itsimmediate effects, IL-2 induces a complex pattern of chronic HPA stimulation. These findings may functionally relate to several CNS disorders and certain endocrine dysfunctions observed during IL-2 immunotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:50:59