Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANGIOGENIC FACTORS - SYNTHESES OF 12(R)HYDROXYEICOSA-5(Z),8(Z),14(Z)-TRIENOIC ACID AND THEIR 14,15-DEHYDRO AND 12(S)HYDROXYEICOSA-5(Z),8(Z),14(Z)-TRIENOIC ACID AND THEIR 14,15-DEHYDRO ANALOGS
Autore:
CHAUHAN K; RAVI D; FALCK JR; STOLTZ RA; LANIADOSCHWARTZMAN M;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT MOLEC GENET & PHARMACOL DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT MOLEC GENET & PHARMACOL DALLAS TX 75235 NEW YORK MED COLL,DEPT PHARMACOL VALHALLA NY 10595
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 22, volume: 4, anno: 1994,
pagine: 2689 - 2692
SICI:
0960-894X(1994)4:22<2689:AF-SO1>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORCINE POLYMORPHONUCLEAR LEUKOCYTES; 12(R)-HYDROXYEICOSATRIENOIC ACID; ARACHIDONATE METABOLITE; REDUCTASE PATHWAY; FATTY-ACIDS; 12-HETE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
K. Chauhan et al., "ANGIOGENIC FACTORS - SYNTHESES OF 12(R)HYDROXYEICOSA-5(Z),8(Z),14(Z)-TRIENOIC ACID AND THEIR 14,15-DEHYDRO AND 12(S)HYDROXYEICOSA-5(Z),8(Z),14(Z)-TRIENOIC ACID AND THEIR 14,15-DEHYDRO ANALOGS", Bioorganic & medicinal chemistry letters, 4(22), 1994, pp. 2689-2692

Abstract

The title autacoids and acetylenic analogs were conveniently preparedfrom 2-deoxy-D-ribose via Barton deoxygenation, cuprate coupling, andWittig homologation. 12(R)-HETrE, but not the 12(S)-isomer, significantly stimulated microvessel endothelial cell proliferation and proto-oncogene mRNA levels at sub-nano to picomolar concentrations. A high affinity binding site for 12(R)-HETrE was detected on microvessel endothelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 07:14:32