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Titolo:
LYMPHOCYTE TRAFFIC AND POSITIONING IN-VIVO
Autore:
DESOUSA M;
Indirizzi:
ABEL SALAZAR INST BIOMED SCI P-4000 OPORTO PORTUGAL
Titolo Testata:
Pathology research and practice
fascicolo: 9-10, volume: 190, anno: 1994,
pagine: 840 - 850
SICI:
0344-0338(1994)190:9-10<840:LTAPI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-ENDOTHELIAL VENULES; AFFERENT LYMPHATIC VESSELS; TUMOR-NECROSIS-FACTOR; CELL-SURFACE MOLECULE; NODE HIGH ENDOTHELIUM; HOMING RECEPTOR; EXTRACELLULAR-MATRIX; T-CELLS; NEURAMINIDASE ACTIVITY; RECIRCULATING LYMPHOCYTES;
Keywords:
LYMPHOCYTES; ECM; CYTOKINES; VLA PROTEINS; HOMING; ENDOTHELIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
103
Recensione:
Indirizzi per estratti:
Citazione:
M. Desousa, "LYMPHOCYTE TRAFFIC AND POSITIONING IN-VIVO", Pathology research and practice, 190(9-10), 1994, pp. 840-850

Abstract

The continuous circulation of lymphocytes between blood and lymph, constitutes, with the specific recognition of foreign antigens and with memory, one of the hallmarks of the immunological system. In the routine process of recirculating between blood and lymph in adult life, lymphocytes display the unique capacity of recognizing ''self within self''. The physiological recognition of ''self within self'' is expressedat three levels: (1) an overall ability to distinguish between peripheral lymphoid and non-lymphoid organs, (2) the ability of lymphocyte subpopulations so discriminate between Peripheral lymphoid organs, (3) a fine recognition of distinct microenvironments within the peripherallymphoid organs. Historically, interest in regulation of entry into the lymph dominated this field, focusing primarily on the interaction of lymphocytes with post-capillary venules with high endothelium found in some higher vertebrate lymph nodes. Lymphocytes, however, enter thelymph in species without lymph nodes, and lymphocytes recirculation is well established in fetal life. Regardless of route of entry, lymphocytes in birds, fish, rodents, and humans enter the peripheral lymphoid organs and display the capacity to segregate and arrange themselves in distinct territories, a phenomenon called ''ecotaxis'' This paper reviews the evidence for the relative contribution of so called specialized lymphocyte endothelium interactions and other interactions, to the physiological regulation of lymphocyte traffic and positioning. Of the latter, interactions of lymphocytes with the ECM appear of some significance for two reasons: there is a selective distribution of some ECM components in peripheral lymph old organ areas, as recently shown for tenascin in the thymus-dependent zones (Chilosi et al., Am J Pathol143: 1348-1355, 1993). This selective distribution may serve as a basis for preferential T cell migration through those zones. The abnormalexpression of tenascin in non-lymphoid organs with autoimmune lesionsmay serve as an identical basis for abnormal T lymphocyte migration in autoimmunity (Chilosi, personal communication). Additional evidence for abnormal cell-ECM interactions playing a role in autoimmune-like lesions comes from the recent observations in TGF-beta 1 knockout mice,in which mononuclear cell infiltration of the heart and lungs has been corrected by the systemic administration of synthetic FN peptides (Hines at al., PNAS 91:5187-5191, 1994). Changes in expression of ECM components have also being described in rat heart allografts preceding lymphocyte accumulation in the pro cess of allograft rejection (Coito et al. Transplantation 57:599-605, 1994). Other pathological situationsmay benefit from the characterization of the molecular basis of lymphocyte - ECM interactions: parasites, bacteria, and tumor cells may compete for binding sites in ECM, utilized normally by lymphocytes. The paper concludes with the view that the next years will see enormous progress in three areas: (1) understanding of the interactions of circulating lymphocytes with ECM, whether directly, or mediated by cytokines,(2) in methods controlling lymphocyte migration to allografts (Kupiec- Weglinski et al., Exp Nephrol 1:78-82, 1993, Coito et al. TransplantProc, in Press), and to autoimmune disease sites, (3) in controlling parasite and turner cell migration. One thing seems certain: ''comme d'habitude'', in Science, the best is yet to come.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:14:38