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Titolo:
STUDIES ON CHEMICAL MODIFICATION OF MONENSIN .5. SYNTHESIS, SODIUM-ION PERMEABILITY, ANTIBACTERIAL ACTIVITY, AND CRYSTAL-STRUCTURE OF 7-O-(4-SUBSTITUTED BENZYL)MONENSINS
Autore:
NAGATSU A; TAKAHASHI T; ISOMURA M; NAGAI S; UEDA T; MURAKAMI N; SAKAKIBARA J; HATANO K;
Indirizzi:
NAGOYA CITY UNIV,FAC PHARMACEUT SCI,MIZUHO KU NAGOYA AICHI 467 JAPAN NAGOYA CITY UNIV,FAC PHARMACEUT SCI,MIZUHO KU NAGOYA AICHI 467 JAPAN
Titolo Testata:
Chemical and Pharmaceutical Bulletin
fascicolo: 11, volume: 42, anno: 1994,
pagine: 2269 - 2275
SICI:
0009-2363(1994)42:11<2269:SOCMOM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Keywords:
MONENSIN; 7-O-(4-SUBSTITUTED BENZYL)MONENSIN; LIPOPHILICITY; SODIUM ION PERMEABILITY; ANTIBACTERIAL ACTIVITY; CRYSTAL STRUCTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
A. Nagatsu et al., "STUDIES ON CHEMICAL MODIFICATION OF MONENSIN .5. SYNTHESIS, SODIUM-ION PERMEABILITY, ANTIBACTERIAL ACTIVITY, AND CRYSTAL-STRUCTURE OF 7-O-(4-SUBSTITUTED BENZYL)MONENSINS", Chemical and Pharmaceutical Bulletin, 42(11), 1994, pp. 2269-2275

Abstract

7-O-(4-Suhstituted benzyl)monensins (3a-g) were synthesized from monensin (1), and their lipophilicity, antibacterial activity, and Na+ ionpermeability were examined. 7-O-(4-Ethylbenzyl)monensin (3e) showed the largest Na+ ion permeability, but 3c,f,g showed smaller Na+ ion permeability than 7-O-benzylmonensin (2) in spite of higher lipophilicity. An X-ray study of the sodium salt of 3e revealed that the benzyl group was located over the position between the D and E rings, and that the ethyl substituent on the benzyl group was close to the C(28) methylgroup an the E ring.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:12:55