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Titolo:
EFFECTS OF TREATMENT WITH IMIPRAMINE AND CLONAZEPAM ON AN ANIMAL-MODEL OF PANIC DISORDER
Autore:
SHEKHAR A;
Indirizzi:
INDIANA UNIV,SCH MED,INST PSYCHIAT RES,DEPT PSYCHIAT,791 UNION DR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,INST PSYCHIAT RES,DEPT PHARMACOL & TOXICOL INDIANAPOLIS IN 46202
Titolo Testata:
Biological psychiatry
fascicolo: 11, volume: 36, anno: 1994,
pagine: 748 - 758
SICI:
0006-3223(1994)36:11<748:EOTWIA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSOMEDIAL HYPOTHALAMIC NUCLEUS; POSTERIOR HYPOTHALAMUS; LOCUS COERULEUS; GABA; RATS; ANXIETY; TRIAL; PROJECTIONS; STIMULATION; ALPRAZOLAM;
Keywords:
GAMMA-AMINOBUTYRIC ACID; DORSOMEDIAL HYPOTHALAMUS; HEART RATE; BLOOD PRESSURE; SOCIAL INTERACTION; ANXIETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A. Shekhar, "EFFECTS OF TREATMENT WITH IMIPRAMINE AND CLONAZEPAM ON AN ANIMAL-MODEL OF PANIC DISORDER", Biological psychiatry, 36(11), 1994, pp. 748-758

Abstract

Tonic GABAergic inhibition in the dorsomedial hypothalamus (DMH) has been shown to regulate a constellation of behavioral and physiologicalresponses that resemble a human panic attack. The present study was aimed at testing if the panic-like response elicited by injecting gamma-aminobutyric acid (GABA) antagonists into the DMH can be blocked by pretreating the animals with the antipanic drugs, imipramine and clonazepam. Rats were fitted with arterial catheters and bilateral chronic microinjection cannulae in the DMH. Their baseline heart rate, respiratory rate, blood pressure and ''anxiety'' (measured by the social interaction test) responses to injection of the GABA, antagonist bicuculline methiodide (BMI) into the DMH were recorded. After treatment in a double-blind manner with vehicle, imipramine (5 and 15 mg/kg, 7 days), and clonazepan (5 mg/kg, 3 days), the response to BMI microinjection into the DMH was once again recorded. Both imipramine and clonazepam, but not vehicle treatments blocked the BMI response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:01:24