Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SODIUM ALTERATIONS IN ISOLATED RAT-HEART DURING CARDIOPLEGIC ARREST
Autore:
SCHEPKIN VD; CHOY IO; BUDINGER TF;
Indirizzi:
UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB,CTR FUNCT IMAGING,1 CYCLOTRON RD,MS 55-121 BERKELEY CA 94720 UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB,CTR FUNCT IMAGING BERKELEY CA 94720
Titolo Testata:
Journal of applied physiology
fascicolo: 6, volume: 81, anno: 1996,
pagine: 2696 - 2702
SICI:
8750-7587(1996)81:6<2696:SAIIRD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FILTERED NA-23 NMR; NUCLEAR-MAGNETIC-RESONANCE; GUINEA-PIG HEART; INTRACELLULAR SODIUM; EXTRACELLULAR CONTRIBUTION; BIEXPONENTIAL RELAXATION; MYOCARDIAL PROTECTION; REPERFUSION INJURY; PERFUSED HEARTS; CELLULAR-ENERGY;
Keywords:
ISCHEMIA-REPERFUSION; NONINVASIVE MONITORING OF SODIUM; NUCLEAR MAGNETIC RESONANCE; TRIPLE-QUANTUM FILTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
V.D. Schepkin et al., "SODIUM ALTERATIONS IN ISOLATED RAT-HEART DURING CARDIOPLEGIC ARREST", Journal of applied physiology, 81(6), 1996, pp. 2696-2702

Abstract

Triple-quantum-filtered (TQF) Na nuclear magnetic resonance (NMR) without chemical shift reagent is used to investigate Na derangement in isolated crystalloid perfused rat hearts during St. Thomas cardioplegic(CP) arrest. The extracellular Na contribution to the NMR TQF signal of a rat heart is found to be 73 +/- 5%, as determined by wash-out-experiments at different moments of ischemia and reperfusion, With the use of this contribution factor, the estimated intracellular Na([Na+](i)) TQF signal is 222 +/- 13% of preischemic level after 40 min of CP arrest and 30 min of reperfusion, and the heart rate pressure product recovery is 71 +/- 8%. These parameters are significantly better than for stop-flow ischemia: 340 +/- 20% and 6 +/- 3%, respectively. At 37 degrees C, the initial delay of 15 min in [Na+]i growth occurs during CParrest along with reduced growth later (similar to 4.0%/min) in comparison with stop-flow ischemia (similar to 6.7%/min). The hypothermia (21 degrees C, 40 min) for the stop-flow ischemia and CP dramatically decreases the [Na+](i) gain with the highest heart recovery for CP (similar to 100%). These studies confirm the enhanced sensitivity of TQF NMR to [Na+](i) and demonstrate the potential of NMR without chemical shift reagent to monitor [Na+](i) derangements.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:10:26