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Titolo:
INTERACTION BETWEEN ENDOTOXIN AND THE ANTITUMOR AGENT 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID IN THE INDUCTION OF TUMOR-NECROSIS-FACTOR AND HEMORRHAGIC NECROSIS OF COLON-38 TUMORS
Autore:
CHING LM; JOSEPH WR; ZHUANG L; BAGULEY BC;
Indirizzi:
UNIV AUCKLAND,SCH MED,CANC RES LAB,PRIVATE BAG 92019 AUCKLAND NEW ZEALAND
Titolo Testata:
Cancer chemotherapy and pharmacology
fascicolo: 2, volume: 35, anno: 1994,
pagine: 153 - 160
SICI:
0344-5704(1994)35:2<153:IBEATA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLAVONE ACETIC-ACID; KILLER CELL-ACTIVITY; MURINE RENAL-CANCER; LPS BINDING-PROTEIN; FLAVONE-8-ACETIC ACID; XANTHENONE-4-ACETIC ACID; TYROSINE PHOSPHORYLATION; LIPOPOLYSACCHARIDE LPS; FACTOR-ALPHA; BLOOD-FLOW;
Keywords:
LIPOPOLYSACCHARIDE; ANTITUMOR ACTIVITY; CYTOKINE; SYNERGISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Ching et al., "INTERACTION BETWEEN ENDOTOXIN AND THE ANTITUMOR AGENT 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID IN THE INDUCTION OF TUMOR-NECROSIS-FACTOR AND HEMORRHAGIC NECROSIS OF COLON-38 TUMORS", Cancer chemotherapy and pharmacology, 35(2), 1994, pp. 153-160

Abstract

The investigational antitumour agent 5,6-dimethyl-xanthenone-4-aceticacid (5,6-MeXAA) induced dose dependent haemorrhagic necrosis of colon 38 tumours to a similar extent to that induced using bacterial lipopolysaccharide (LPS). TNF-alpha activity in serum and mRNA for TNF-alpha in splenocytes were induced over a broad range of LPS doses, whereaswith 5,6-MeXAA, induction occurred Only at concentrations approachingthe maximum tolerated dose. At concentrations that provided similar degrees of haemorrhagic necrosis, the levels of serum TNF-alpha inducedusing 5,6-MeXAA were 100-fold lower than those obtained with LPS, indicating that haemorrhagic necrosis was not directly correlated with TNF-alpha levels. There was also no correlation between the degree of tumour necrosis and the duration of growth delay. Treatment with LPS didnot induce a significant delay in growth, despite extensive tumour haemorrhagic necrosis, whereas with 5,6-MeXAA, treatments that improved the cure rate did not necessarily give longer growth delays. Therapy using a combination of sub-optimal doses of both compounds was synergistic for the induction of serum TNF-alpha and message for TNF-alpha butwas not synergistic for antitumour efficacy. Thus, no correlation is evident between cure rates, duration of growth delay, haemorrhagic necrosis and TNF-alpha induction by 5,6-MeXAA or LPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:25:27