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Titolo: CD4-IGG BINDING THRESHOLD FOR INACTIVATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
Autore: BERKOWER I; MOSTOWSKI H; BULL TE; MURPHY D;
- Indirizzi:
- NIH,IMMUNOREGULAT LAB,OFF VACCINE RES,CTR BIOL,FDA,BLDG 29,ROOM 523,NIH CAMPUS BETHESDA MD 20892 NIH,BIOPHYS LAB,OFF VACCINE RES,CTR BIOL,FDA BETHESDA MD 20892
- Titolo Testata:
- The Journal of infectious diseases
fascicolo: 4,
volume: 173,
anno: 1996,
pagine: 863 - 869
- SICI:
- 0022-1899(1996)173:4<863:CBTFIO>2.0.ZU;2-J
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- HUMAN MONOCLONAL-ANTIBODY; RECOMBINANT SOLUBLE CD4; ENVELOPE GLYCOPROTEIN-GP120; NEUTRALIZING ANTIBODIES; CELL RECEPTORS; AIDS VIRUS; HTLV-III; T-CELLS; GP120; HIV;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 34
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- I. Berkower et al., "CD4-IGG BINDING THRESHOLD FOR INACTIVATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1", The Journal of infectious diseases, 173(4), 1996, pp. 863-869
Abstract
The stoichiometry of human immunodeficiency virus type 1 (HIV-1) inactivation by soluble receptor CD4-IgG hybrid dimers (CD4-IgG) was examined. The extent of HIV-1 inactivation was measured in a sensitive plaque-forming assay, and the corresponding level of CD4-IgG binding was determined by immunofluorescence of infected cells, Ninety percent virus inactivation occurred at relatively low levels of CD4-IgG binding (10% of the saturating level). At even lower binding levels (1.4% of maximum binding), virus survival was 44%. Over a broad range of binding conditions, the survival curve followed a model in which viruses binding more than a threshold level of CD4-IgG were completely inactivated, while viruses binding less remained infectious, The data indicate thatCD4-IgG binding to 1.4% of gp120 binding sites equals the threshold for inactivation, Thus, virus inactivation can begin when 3 CD4-IgG (ofsimilar to 216 gp120 sites) bind per virion.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:41:26