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Titolo:
BIOAVAILABILITY AND EFFICACY OF OMEPRAZOLE GIVEN ORALLY AND BY NASOGASTRIC TUBE
Autore:
LARSON C; CAVUTO NJ; FLOCKHART DA; WEINBERG RB;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT INTERNAL MED,GASTROENTEROL SECT,MED CTR BLVD WINSTON SALEM NC 27157 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT INTERNAL MED,GASTROENTEROL SECT WINSTON SALEM NC 27157 MASSACHUSETTS GEN HOSP,DEPT PEDIAT,DIV GASTROENTEROL BOSTON MA 02114 GEORGETOWN UNIV,MED CTR,DEPT MED,DIV CLIN PHARMACOL WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL,DIV CLIN PHARMACOL WASHINGTON DC 20007
Titolo Testata:
Digestive diseases and sciences
fascicolo: 3, volume: 41, anno: 1996,
pagine: 475 - 479
SICI:
0163-2116(1996)41:3<475:BAEOOG>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-SECRETION; S-MEPHENYTOIN; GASTRIC-ACID; HYDROXYLATION; POLYMORPHISM; DEBRISOQUIN; POPULATIONS; INHIBITOR; SINGLE;
Keywords:
OMEPRAZOLE; GASTRIC ACID SECRETION; NASOGASTRIC TUBE; PHARMACOKINETICS; PENTAGASTRIN; CYTOCHROME P-450; BIOAVAILABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
C. Larson et al., "BIOAVAILABILITY AND EFFICACY OF OMEPRAZOLE GIVEN ORALLY AND BY NASOGASTRIC TUBE", Digestive diseases and sciences, 41(3), 1996, pp. 475-479

Abstract

We compared the bioavailability and the efficacy of omeprazole provided either as encapsulated enteric-coated granules or as enteric-coatedgranules delivered via a nasogastric tube in 10 healthy subjects. Omeprazole reduced mean pentagastrin-stimulated peak gastric acid secretion by 85.5% +/- 23.7% when delivered orally and by 79.6% +/- 32.1% when delivered by nasogastric tube; the mean plasma omeprazole concentration area under the curve (AUG) was 2.02 +/- 0.79 after oral delivery and 1.74 +/- 1.89 after nasogastric tube delivery. There was no significant difference in these parameters between the two routes of administration, and there was excellent intrasubject correlation between oral and nasogastric percent acid suppression and AUC. There was a close correlation between AUC and percent acid suppression at AUC values below0.6, and complete acid suppression at AUC values above 0.6, regardless of the delivery route. We conclude that omeprazole delivered as enteric-coated granules via nasogastric tube provides equal bioavailability and gastric acid suppression as omeprazole given orally in its proprietary formulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:01:13