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Titolo:
FROM INDOMETHACIN TO A SELECTIVE COX-2 INHIBITOR - DEVELOPMENT OF INDOLALKANOIC ACIDS AS POTENT AND SELECTIVE CYCLOOXYGENASE-2 INHIBITORS
Autore:
BLACK WC; BAYLY C; BELLEY M; CHAN CC; CHARLESON S; DENIS D; GAUTHIER JY; GORDON R; GUAY D; KARGMAN S; LAU CK; LEBLANC Y; MANCINI J; OUELLET M; PERCIVAL D; ROY P; SKOREY K; TAGARI P; VICKERS P; WONG E; XU L; PRASIT P;
Indirizzi:
MERCK FROSST CTR THERAPEUT RES,POB 1005 POINTE CLAIRE PQ H9R 4P8 CANADA
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 6, volume: 6, anno: 1996,
pagine: 725 - 730
SICI:
0960-894X(1996)6:6<725:FITASC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SYNTHASE; PROFILE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
W.C. Black et al., "FROM INDOMETHACIN TO A SELECTIVE COX-2 INHIBITOR - DEVELOPMENT OF INDOLALKANOIC ACIDS AS POTENT AND SELECTIVE CYCLOOXYGENASE-2 INHIBITORS", Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 725-730

Abstract

A series of potent and highly selective cyclooxygenase-2 inhibitors have been prepared by replacing the benzoyl group of indomethacin with a 4-bromobenzyl group, and by extending the acetic acid side chain. These compounds show anti-inflammatory activity in rats with no evidenceof GI toxicity, even at high doses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:46:25