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Titolo:
AXONS OF XENOPUS NEURAL-TUBE RESPOND TO REVERSALS OF NEURAL-TUBE ORIENTATION
Autore:
NORDLANDER RH; LIU SX;
Indirizzi:
OHIO STATE UNIV,DEPT ORAL BIOL COLUMBUS OH 43210 OHIO STATE UNIV,DEPT CELL BIOL NEUROBIOL & ANAT COLUMBUS OH 43210
Titolo Testata:
Journal of neurobiology
fascicolo: 4, volume: 29, anno: 1996,
pagine: 490 - 502
SICI:
0022-3034(1996)29:4<490:AOXNRT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUID-CONTACTING NEURONS; RETINOIC ACID; SPINAL-CORD; GABA IMMUNOCYTOCHEMISTRY; MOLECULAR GRADIENTS; HOMING BEHAVIOR; NERVOUS-SYSTEM; FROG EMBRYOS; EXPRESSION; GUIDANCE;
Keywords:
AXONAL GUIDANCE; ANTEROPOSTERIOR POLARITY; KOLMER-AGDUHR CELLS; GROWTH CONE; FROG EMBRYO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
R.H. Nordlander e S.X. Liu, "AXONS OF XENOPUS NEURAL-TUBE RESPOND TO REVERSALS OF NEURAL-TUBE ORIENTATION", Journal of neurobiology, 29(4), 1996, pp. 490-502

Abstract

Axonal trajectories of the Kolmer-Agduhr (KA) neurons of Xenopus embryos, were observed after anterior-posterior (A-P) inversions of neuraltube grafts to determine whether KA axons follow cell-inherent directional cues, cues from their immediate environment, or rostrocaudal signals from the embryo. ICA axons form one of the earliest ascending spinal pathways in Xenopus and are visible in the lateral marginal zone of whole mounts processed for GABA immunoreactivity. Grafts were made at trunk levels at stages 22-24, 3-5 h before the first KA neurons weredetectable and prior to axonal outgrowth. Embryos were fixed and immunostained 6-36 h later. KA trajectories within and adjacent to reversed grafts were compared to those of nonrotated control grafts and to neural tube lengths comparable in position and in length in unoperated embryos. Most KA axons within rotated grafts followed the graft's orientation. However, others changed direction, taking novel routes, including turning to conform to the orientation of the host embryo. Reorientations were most common near the posterior host/graft interface. Some host KA cells also reoriented, always within a few hundred microns of the graft interface. Taken together, these growth patterns show that most KA axons within the grafts grow normally with respect to the original polarity of the graft neural tube and maintain that direction eveninto tissue of opposite polarity, suggesting that their routes are mainly determined by cell-intrinsic and/or local tissue factors. However, the reorientation of many other axons, particularly near graft seams, implies that KA axons can respond to local fluctuations in directional or segment identity signals generated in both host and graft after this perturbation. (C) 1996 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:52:38