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Titolo:
INTRARECTAL QUINIMAX(R) (A COMBINATION OF CINCHONA ALKALOIDS) ADMINISTERED AT 3 DIFFERENT DOSAGES TO CHILDREN WITH PLASMODIUM-FALCIPARUM MALARIA IN NIGER
Autore:
BARENNES H; PUSSARD E; SANI AM; CLAVIER F; HENZEL D; KAHIATANI F; GRANIC G; RAVINET L; VERDIER F;
Indirizzi:
HOP BICHAT CLAUDE BERNARD,INSERM U13,IMEA,46 RUE HENRI HUCHARD F-75877 PARIS 18 FRANCE COOPERAT FRANCAISE,MINIST SANTE PUBL NIGER NIAMEY NIGER INST MED & EPIDEMIOL AFRICAINES & TROP,INSERM,U13 PARIS FRANCE FAC SCI MED NIAMEY NIAMEY NIGER HOP NIAMEY NIAMEY NIGER SANOFI WINTHROP GENTILLY FRANCE
Titolo Testata:
Clinical drug investigation
fascicolo: 3, volume: 11, anno: 1996,
pagine: 154 - 158
SICI:
1173-2563(1996)11:3<154:IQ(COC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
H. Barennes et al., "INTRARECTAL QUINIMAX(R) (A COMBINATION OF CINCHONA ALKALOIDS) ADMINISTERED AT 3 DIFFERENT DOSAGES TO CHILDREN WITH PLASMODIUM-FALCIPARUM MALARIA IN NIGER", Clinical drug investigation, 11(3), 1996, pp. 154-158

Abstract

In order to optimise the intrarectal administration of Quinimax(R). this combination of Cinchona alkaloids uas administered intrarectally at 3 different dosages to 13 children with acute uncomplicated Plasmodium, falciparum, malaria in Niger. Four children received 8 mg/kg and 5received 13 mg/kg every 8 hours for 3 days. A further 4 children received 20 mg/kg every 12 hours for 3 days. The clinical and parasitological status of the children was similar in the 3 groups at admission. Temperature fell stably to normal at 36 hours with all 3 regimens. Total clearance of parasitaemia was only obtained at 48; hours with the 20mg/kg regimen. All the patients were aparasitaemic by day 7. Whole blood quinine concentrations increased linearly with the 3 doses, Even though the 20 mg/kg 12-hourly regimen led to the highest peal; concentrations of quinine, trough concentrations were lower than those obtained with the other 2 regimens. Pharmacokinetic simulation allowed us to propose that intrarectal administration of Quinimax(R) 20 mg/kg every 8 hours will lead to effective and nontoxic quinine concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 14:32:07